Yeasts in nanotechnology-enabled oral vaccine and gene delivery

Oral vaccine and gene delivery systems must be engineered to withstand several different physiological environments, such as those present in the oral cavity, stomach, and jejunum, each of which exhibits varying pH levels and enzyme distributions. Additionally, these systems must be designed to ensu...

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Main Author:	Elena Ivanova
Format:	article
Language:	EN
Published:	Taylor & Francis Group 2021
Subjects:	oral vaccines synthetic yeast gene delivery nanoparticles Biotechnology TP248.13-248.65
Online Access:	https://doaj.org/article/90a7907618604ef0acfc7994ba7c83a4
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id	oai:doaj.org-article:90a7907618604ef0acfc7994ba7c83a4
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spelling	oai:doaj.org-article:90a7907618604ef0acfc7994ba7c83a42021-11-04T15:51:53ZYeasts in nanotechnology-enabled oral vaccine and gene delivery2165-59792165-598710.1080/21655979.2021.1985816https://doaj.org/article/90a7907618604ef0acfc7994ba7c83a42021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1985816https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Oral vaccine and gene delivery systems must be engineered to withstand several different physiological environments, such as those present in the oral cavity, stomach, and jejunum, each of which exhibits varying pH levels and enzyme distributions. Additionally, these systems must be designed to ensure appropriate gastrointestinal absorption and tissue/cellular targeting properties. Yeasts-based delivery vehicles are excellent candidates for oral vaccine and oral gene therapies as many species possess cellular characteristics resulting in enhanced resistance to the harsh gastrointestinal (GI) environment and facilitated passage across the mucosal barrier. Yeast capsules can stimulate and modulate host immune responses, which is beneficial for vaccine efficacy. In addition, recombinant modification of yeasts to express cell penetrating proteins and injection mechanisms along with efficient cell adhering capabilities can potentially improve transfection rates of genetic material. In this literature review, we present evidence supporting the beneficial role yeast-based delivery systems can play in increasing the efficacy of oral administration of vaccines and gene therapies.Elena IvanovaTaylor & Francis Grouparticleoral vaccinessynthetic yeastgene deliverynanoparticlesBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 1, Pp 8325-8335 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral vaccines synthetic yeast gene delivery nanoparticles Biotechnology TP248.13-248.65
spellingShingle	oral vaccines synthetic yeast gene delivery nanoparticles Biotechnology TP248.13-248.65 Elena Ivanova Yeasts in nanotechnology-enabled oral vaccine and gene delivery
description	Oral vaccine and gene delivery systems must be engineered to withstand several different physiological environments, such as those present in the oral cavity, stomach, and jejunum, each of which exhibits varying pH levels and enzyme distributions. Additionally, these systems must be designed to ensure appropriate gastrointestinal absorption and tissue/cellular targeting properties. Yeasts-based delivery vehicles are excellent candidates for oral vaccine and oral gene therapies as many species possess cellular characteristics resulting in enhanced resistance to the harsh gastrointestinal (GI) environment and facilitated passage across the mucosal barrier. Yeast capsules can stimulate and modulate host immune responses, which is beneficial for vaccine efficacy. In addition, recombinant modification of yeasts to express cell penetrating proteins and injection mechanisms along with efficient cell adhering capabilities can potentially improve transfection rates of genetic material. In this literature review, we present evidence supporting the beneficial role yeast-based delivery systems can play in increasing the efficacy of oral administration of vaccines and gene therapies.
format	article
author	Elena Ivanova
author_facet	Elena Ivanova
author_sort	Elena Ivanova
title	Yeasts in nanotechnology-enabled oral vaccine and gene delivery
title_short	Yeasts in nanotechnology-enabled oral vaccine and gene delivery
title_full	Yeasts in nanotechnology-enabled oral vaccine and gene delivery
title_fullStr	Yeasts in nanotechnology-enabled oral vaccine and gene delivery
title_full_unstemmed	Yeasts in nanotechnology-enabled oral vaccine and gene delivery
title_sort	yeasts in nanotechnology-enabled oral vaccine and gene delivery
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/90a7907618604ef0acfc7994ba7c83a4
work_keys_str_mv	AT elenaivanova yeastsinnanotechnologyenabledoralvaccineandgenedelivery
_version_	1718444727767924736

Yeasts in nanotechnology-enabled oral vaccine and gene delivery

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