Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure

Abstract Obesity is associated with a “natriuretic handicap” indicated by reduced N-terminal fragment of proBNP (NT-proBNP) concentration. While gastric bypass surgery improves the natriuretic handicap, it is presently unclear if sleeve gastrectomy exhibits similar effects. We examined NT-proBNP ser...

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Autores principales:	Tim Hollstein, Kristina Schlicht, Laura Krause, Stefanie Hagen, Nathalie Rohmann, Dominik M. Schulte, Kathrin Türk, Alexia Beckmann, Markus Ahrens, Andre Franke, Stefan Schreiber, Thomas Becker, Jan Beckmann, Matthias Laudes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90a850667c534f679a35828088d8220c
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spelling	oai:doaj.org-article:90a850667c534f679a35828088d8220c2021-12-02T16:50:31ZEffect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure10.1038/s41598-021-89426-72045-2322https://doaj.org/article/90a850667c534f679a35828088d8220c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89426-7https://doaj.org/toc/2045-2322Abstract Obesity is associated with a “natriuretic handicap” indicated by reduced N-terminal fragment of proBNP (NT-proBNP) concentration. While gastric bypass surgery improves the natriuretic handicap, it is presently unclear if sleeve gastrectomy exhibits similar effects. We examined NT-proBNP serum concentration in n = 72 obese participants without heart failure before and 6 months after sleeve gastrectomy (n = 28), gastric bypass surgery (n = 19), and 3-month 800 kcal/day very-low calorie diet (n = 25). A significant weight loss was observed in all intervention groups. Within 6 months, NT-proBNP concentration tended to increase by a median of 44.3 pg/mL in the sleeve gastrectomy group (p = 0.07), while it remained unchanged in the other groups (all p ≥ 0.50). To gain insights into potential effectors, we additionally analyzed NT-proBNP serum concentration in n = 387 individuals with different metabolic phenotypes. Here, higher NT-proBNP levels were associated with lower nutritional fat and protein but not with carbohydrate intake. Of interest, NT-proBNP serum concentrations were inversely correlated with fasting glucose concentration in euglycemic individuals but not in individuals with prediabetes or type 2 diabetes. In conclusion, sleeve gastrectomy tended to increase NT-proBNP levels in obese individuals and might improve the obesity-associated “natriuretic handicap”. Thereby, nutritional fat and protein intake and the individual glucose homeostasis might be metabolic determinants of NT-proBNP serum concentration.Tim HollsteinKristina SchlichtLaura KrauseStefanie HagenNathalie RohmannDominik M. SchulteKathrin TürkAlexia BeckmannMarkus AhrensAndre FrankeStefan SchreiberThomas BeckerJan BeckmannMatthias LaudesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tim Hollstein Kristina Schlicht Laura Krause Stefanie Hagen Nathalie Rohmann Dominik M. Schulte Kathrin Türk Alexia Beckmann Markus Ahrens Andre Franke Stefan Schreiber Thomas Becker Jan Beckmann Matthias Laudes Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure
description	Abstract Obesity is associated with a “natriuretic handicap” indicated by reduced N-terminal fragment of proBNP (NT-proBNP) concentration. While gastric bypass surgery improves the natriuretic handicap, it is presently unclear if sleeve gastrectomy exhibits similar effects. We examined NT-proBNP serum concentration in n = 72 obese participants without heart failure before and 6 months after sleeve gastrectomy (n = 28), gastric bypass surgery (n = 19), and 3-month 800 kcal/day very-low calorie diet (n = 25). A significant weight loss was observed in all intervention groups. Within 6 months, NT-proBNP concentration tended to increase by a median of 44.3 pg/mL in the sleeve gastrectomy group (p = 0.07), while it remained unchanged in the other groups (all p ≥ 0.50). To gain insights into potential effectors, we additionally analyzed NT-proBNP serum concentration in n = 387 individuals with different metabolic phenotypes. Here, higher NT-proBNP levels were associated with lower nutritional fat and protein but not with carbohydrate intake. Of interest, NT-proBNP serum concentrations were inversely correlated with fasting glucose concentration in euglycemic individuals but not in individuals with prediabetes or type 2 diabetes. In conclusion, sleeve gastrectomy tended to increase NT-proBNP levels in obese individuals and might improve the obesity-associated “natriuretic handicap”. Thereby, nutritional fat and protein intake and the individual glucose homeostasis might be metabolic determinants of NT-proBNP serum concentration.
format	article
author	Tim Hollstein Kristina Schlicht Laura Krause Stefanie Hagen Nathalie Rohmann Dominik M. Schulte Kathrin Türk Alexia Beckmann Markus Ahrens Andre Franke Stefan Schreiber Thomas Becker Jan Beckmann Matthias Laudes
author_facet	Tim Hollstein Kristina Schlicht Laura Krause Stefanie Hagen Nathalie Rohmann Dominik M. Schulte Kathrin Türk Alexia Beckmann Markus Ahrens Andre Franke Stefan Schreiber Thomas Becker Jan Beckmann Matthias Laudes
author_sort	Tim Hollstein
title	Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure
title_short	Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure
title_full	Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure
title_fullStr	Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure
title_full_unstemmed	Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure
title_sort	effect of various weight loss interventions on serum nt-probnp concentration in severe obese subjects without clinical manifest heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90a850667c534f679a35828088d8220c
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Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure

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