Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer

Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8+ T cells predicts treatment outcome in patients with metastatic gast...

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Autores principales:	Hyun Mu Shin, Gwanghun Kim, Sangjib Kim, Ji Hyun Sim, Jiyeob Choi, Minji Kim, Minsuk Kwon, Sang-Kyu Ye, Dong-Sup Lee, Seung Woo Cho, Seung Tae Kim, Jeeyun Lee, Hang-Rae Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90aa9faac7854b7a8f1dcadb3ad37005
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spelling	oai:doaj.org-article:90aa9faac7854b7a8f1dcadb3ad370052021-12-02T13:30:20ZChromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer10.1038/s41467-021-21299-w2041-1723https://doaj.org/article/90aa9faac7854b7a8f1dcadb3ad370052021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21299-whttps://doaj.org/toc/2041-1723Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8+ T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab.Hyun Mu ShinGwanghun KimSangjib KimJi Hyun SimJiyeob ChoiMinji KimMinsuk KwonSang-Kyu YeDong-Sup LeeSeung Woo ChoSeung Tae KimJeeyun LeeHang-Rae KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyun Mu Shin Gwanghun Kim Sangjib Kim Ji Hyun Sim Jiyeob Choi Minji Kim Minsuk Kwon Sang-Kyu Ye Dong-Sup Lee Seung Woo Cho Seung Tae Kim Jeeyun Lee Hang-Rae Kim Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
description	Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8+ T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab.
format	article
author	Hyun Mu Shin Gwanghun Kim Sangjib Kim Ji Hyun Sim Jiyeob Choi Minji Kim Minsuk Kwon Sang-Kyu Ye Dong-Sup Lee Seung Woo Cho Seung Tae Kim Jeeyun Lee Hang-Rae Kim
author_facet	Hyun Mu Shin Gwanghun Kim Sangjib Kim Ji Hyun Sim Jiyeob Choi Minji Kim Minsuk Kwon Sang-Kyu Ye Dong-Sup Lee Seung Woo Cho Seung Tae Kim Jeeyun Lee Hang-Rae Kim
author_sort	Hyun Mu Shin
title	Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
title_short	Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
title_full	Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
title_fullStr	Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
title_full_unstemmed	Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
title_sort	chromatin accessibility of circulating cd8+ t cells predicts treatment response to pd-1 blockade in patients with gastric cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90aa9faac7854b7a8f1dcadb3ad37005
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Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer

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