A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling induces apoptosis in these cells.

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Autores principales: Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/90ab601100a74a6da15edcbbea0a9c4e
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spelling oai:doaj.org-article:90ab601100a74a6da15edcbbea0a9c4e2021-12-02T15:35:38ZA kinase-independent role for CDK8 in BCR-ABL1+ leukemia10.1038/s41467-019-12656-x2041-1723https://doaj.org/article/90ab601100a74a6da15edcbbea0a9c4e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12656-xhttps://doaj.org/toc/2041-1723Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling induces apoptosis in these cells.Ingeborg MenzlTinghu ZhangAngelika Berger-BecvarReinhard GrausenburgerGerwin HellerMichaela Prchal-MurphyLeo EdlingerVanessa M. KnabIris Z. UrasEva GrundschoberKarin BauerMareike RothAnna SkuchaYao LiuJohn M. HatcherYanke LiangNicholas P. KwiatkowskiDaniela FuxAndrea Hoelbl-KovacicStefan KubicekJunia V. MeloPeter ValentThomas WeichhartFlorian GrebienJohannes ZuberNathanael S. GrayVeronika SexlNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ingeborg Menzl
Tinghu Zhang
Angelika Berger-Becvar
Reinhard Grausenburger
Gerwin Heller
Michaela Prchal-Murphy
Leo Edlinger
Vanessa M. Knab
Iris Z. Uras
Eva Grundschober
Karin Bauer
Mareike Roth
Anna Skucha
Yao Liu
John M. Hatcher
Yanke Liang
Nicholas P. Kwiatkowski
Daniela Fux
Andrea Hoelbl-Kovacic
Stefan Kubicek
Junia V. Melo
Peter Valent
Thomas Weichhart
Florian Grebien
Johannes Zuber
Nathanael S. Gray
Veronika Sexl
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
description Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling induces apoptosis in these cells.
format article
author Ingeborg Menzl
Tinghu Zhang
Angelika Berger-Becvar
Reinhard Grausenburger
Gerwin Heller
Michaela Prchal-Murphy
Leo Edlinger
Vanessa M. Knab
Iris Z. Uras
Eva Grundschober
Karin Bauer
Mareike Roth
Anna Skucha
Yao Liu
John M. Hatcher
Yanke Liang
Nicholas P. Kwiatkowski
Daniela Fux
Andrea Hoelbl-Kovacic
Stefan Kubicek
Junia V. Melo
Peter Valent
Thomas Weichhart
Florian Grebien
Johannes Zuber
Nathanael S. Gray
Veronika Sexl
author_facet Ingeborg Menzl
Tinghu Zhang
Angelika Berger-Becvar
Reinhard Grausenburger
Gerwin Heller
Michaela Prchal-Murphy
Leo Edlinger
Vanessa M. Knab
Iris Z. Uras
Eva Grundschober
Karin Bauer
Mareike Roth
Anna Skucha
Yao Liu
John M. Hatcher
Yanke Liang
Nicholas P. Kwiatkowski
Daniela Fux
Andrea Hoelbl-Kovacic
Stefan Kubicek
Junia V. Melo
Peter Valent
Thomas Weichhart
Florian Grebien
Johannes Zuber
Nathanael S. Gray
Veronika Sexl
author_sort Ingeborg Menzl
title A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
title_short A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
title_full A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
title_fullStr A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
title_full_unstemmed A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
title_sort kinase-independent role for cdk8 in bcr-abl1+ leukemia
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/90ab601100a74a6da15edcbbea0a9c4e
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