Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.

<h4>Background</h4>Gene-gene interactions may be partly responsible for complex traits such as obesity. Increasing evidence suggests that the renin-angiotensin system (RAS) contributes to the etiology of obesity. How the epistasis of genes in the RAS contributes to obesity is still under...

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Autores principales:	Jian-Bo Zhou, Chang Liu, Wen-Yan Niu, Zhong Xin, Mei Yu, Jian-Ping Feng, Jin-Kui Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90ac6ab06e61458da8bcdf90058ee9fe
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spelling	oai:doaj.org-article:90ac6ab06e61458da8bcdf90058ee9fe2021-11-18T07:09:30ZContributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.1932-620310.1371/journal.pone.0042881https://doaj.org/article/90ac6ab06e61458da8bcdf90058ee9fe2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880127/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Gene-gene interactions may be partly responsible for complex traits such as obesity. Increasing evidence suggests that the renin-angiotensin system (RAS) contributes to the etiology of obesity. How the epistasis of genes in the RAS contributes to obesity is still under research. We aim to evaluate the contribution of RAS-related gene interactions to a predisposition of obesity in a Chinese population.<h4>Methodology and principal findings</h4>We selected six single nucleotide polymorphisms (SNPs) located in angiotensin (AGT), angiotensin converting enzyme (ACE), angiotensin type 1 receptor (AGTR1), MAS1, nitric oxide synthase 3 (NOS3) and the bradykinin B2 receptor gene (BDKRB2), and genotyped them in 324 unrelated individuals with obesity (BMI ≥ 28 kg/m(2)) and 373 non-obese controls (BMI 18.5 to <24 kg/m(2)) from a large scale population-based cohort. We analyzed gene-gene interactions among 6 polymorphic loci using the Generalized Multifactor Dimensionality Reduction (GMDR) method, which has been shown to be effective for detecting gene-gene interactions in case-control studies with relatively small samples. Then we used logistic regression models to confirm the best combination of loci identified in the GMDR. It showed a significant gene-gene interaction between the rs220721 polymorphism in the MAS1 gene and the rs1799722 polymorphism in the gene BDKB2R. The best two-locus combination scored 9 for cross-validation consistency and 9 for sign test (p = 0.0107). This interaction showed the maximum consistency and minimum prediction error among all gene-gene interaction models evaluated. Moreover, the combination of the MAS1 rs220721 and the BDKRB2 rs1799722 was associated with a significantly increased risk of obesity (OR 1.82, CI 95%: 1.15-2.88, p = 0.0103).<h4>Conclusions and significance</h4>These results suggest that the SNPs from the RAS-related genes may contribute to the risk of obesity in an interactive manner in a Chinese population. The gene-gene interaction may serve as a novel area for obesity research.Jian-Bo ZhouChang LiuWen-Yan NiuZhong XinMei YuJian-Ping FengJin-Kui YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42881 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Bo Zhou Chang Liu Wen-Yan Niu Zhong Xin Mei Yu Jian-Ping Feng Jin-Kui Yang Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.
description	<h4>Background</h4>Gene-gene interactions may be partly responsible for complex traits such as obesity. Increasing evidence suggests that the renin-angiotensin system (RAS) contributes to the etiology of obesity. How the epistasis of genes in the RAS contributes to obesity is still under research. We aim to evaluate the contribution of RAS-related gene interactions to a predisposition of obesity in a Chinese population.<h4>Methodology and principal findings</h4>We selected six single nucleotide polymorphisms (SNPs) located in angiotensin (AGT), angiotensin converting enzyme (ACE), angiotensin type 1 receptor (AGTR1), MAS1, nitric oxide synthase 3 (NOS3) and the bradykinin B2 receptor gene (BDKRB2), and genotyped them in 324 unrelated individuals with obesity (BMI ≥ 28 kg/m(2)) and 373 non-obese controls (BMI 18.5 to <24 kg/m(2)) from a large scale population-based cohort. We analyzed gene-gene interactions among 6 polymorphic loci using the Generalized Multifactor Dimensionality Reduction (GMDR) method, which has been shown to be effective for detecting gene-gene interactions in case-control studies with relatively small samples. Then we used logistic regression models to confirm the best combination of loci identified in the GMDR. It showed a significant gene-gene interaction between the rs220721 polymorphism in the MAS1 gene and the rs1799722 polymorphism in the gene BDKB2R. The best two-locus combination scored 9 for cross-validation consistency and 9 for sign test (p = 0.0107). This interaction showed the maximum consistency and minimum prediction error among all gene-gene interaction models evaluated. Moreover, the combination of the MAS1 rs220721 and the BDKRB2 rs1799722 was associated with a significantly increased risk of obesity (OR 1.82, CI 95%: 1.15-2.88, p = 0.0103).<h4>Conclusions and significance</h4>These results suggest that the SNPs from the RAS-related genes may contribute to the risk of obesity in an interactive manner in a Chinese population. The gene-gene interaction may serve as a novel area for obesity research.
format	article
author	Jian-Bo Zhou Chang Liu Wen-Yan Niu Zhong Xin Mei Yu Jian-Ping Feng Jin-Kui Yang
author_facet	Jian-Bo Zhou Chang Liu Wen-Yan Niu Zhong Xin Mei Yu Jian-Ping Feng Jin-Kui Yang
author_sort	Jian-Bo Zhou
title	Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.
title_short	Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.
title_full	Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.
title_fullStr	Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.
title_full_unstemmed	Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.
title_sort	contributions of renin-angiotensin system-related gene interactions to obesity in a chinese population.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/90ac6ab06e61458da8bcdf90058ee9fe
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Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.

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