Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia
The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here, the authors show that IGH-DUX4 translocation occurs on the silenced IGH allele avoiding toxic high-level expression of DUX4 in B-ALL.
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Nature Portfolio
2019
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oai:doaj.org-article:90ad9d14a77c46e7933be6cc138b05a82021-12-02T15:36:24ZLong-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia10.1038/s41467-019-10637-82041-1723https://doaj.org/article/90ad9d14a77c46e7933be6cc138b05a82019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10637-8https://doaj.org/toc/2041-1723The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here, the authors show that IGH-DUX4 translocation occurs on the silenced IGH allele avoiding toxic high-level expression of DUX4 in B-ALL.Liqing TianYing ShaoStephanie NanceJinjun DangBeisi XuXiaotu MaYongjin LiBensheng JuLi DongScott NewmanXin ZhouPatrick SchreinerElizabeth TsengTing HonMeredith AshbyChunliang LiJohn EastonTanja A. GruberJinghui ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Liqing Tian Ying Shao Stephanie Nance Jinjun Dang Beisi Xu Xiaotu Ma Yongjin Li Bensheng Ju Li Dong Scott Newman Xin Zhou Patrick Schreiner Elizabeth Tseng Ting Hon Meredith Ashby Chunliang Li John Easton Tanja A. Gruber Jinghui Zhang Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia |
| description |
The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here, the authors show that IGH-DUX4 translocation occurs on the silenced IGH allele avoiding toxic high-level expression of DUX4 in B-ALL. |
| format |
article |
| author |
Liqing Tian Ying Shao Stephanie Nance Jinjun Dang Beisi Xu Xiaotu Ma Yongjin Li Bensheng Ju Li Dong Scott Newman Xin Zhou Patrick Schreiner Elizabeth Tseng Ting Hon Meredith Ashby Chunliang Li John Easton Tanja A. Gruber Jinghui Zhang |
| author_facet |
Liqing Tian Ying Shao Stephanie Nance Jinjun Dang Beisi Xu Xiaotu Ma Yongjin Li Bensheng Ju Li Dong Scott Newman Xin Zhou Patrick Schreiner Elizabeth Tseng Ting Hon Meredith Ashby Chunliang Li John Easton Tanja A. Gruber Jinghui Zhang |
| author_sort |
Liqing Tian |
| title |
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia |
| title_short |
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia |
| title_full |
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia |
| title_fullStr |
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia |
| title_full_unstemmed |
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia |
| title_sort |
long-read sequencing unveils igh-dux4 translocation into the silenced igh allele in b-cell acute lymphoblastic leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/90ad9d14a77c46e7933be6cc138b05a8 |
| work_keys_str_mv |
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1718386303157927936 |