Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function

Abstract A frailty index (FI) counts health deficit accumulation. Besides traditional risk factors, it is unknown whether the health deficit burden is related to the appearance of cardiovascular disease. In order to answer this question, the same multidimensional FI looking at 45-health deficits was...

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Autores principales:	Constantin-Cristian Topriceanu, James C. Moon, Rebecca Hardy, Nishi Chaturvedi, Alun D. Hughes, Gabriella Captur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90af7d40e50b4543a8ebaa2bae94121b
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spelling	oai:doaj.org-article:90af7d40e50b4543a8ebaa2bae94121b2021-12-02T16:31:11ZLongitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function10.1038/s41598-021-85435-82045-2322https://doaj.org/article/90af7d40e50b4543a8ebaa2bae94121b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85435-8https://doaj.org/toc/2045-2322Abstract A frailty index (FI) counts health deficit accumulation. Besides traditional risk factors, it is unknown whether the health deficit burden is related to the appearance of cardiovascular disease. In order to answer this question, the same multidimensional FI looking at 45-health deficits was serially calculated per participant at 4 time periods (0–16, 19–44, 45–54 and 60–64 years) using data from the 1946 Medical Research Council (MRC) British National Survey of Health and Development (NSHD)—the world’s longest running longitudinal birth cohort with continuous follow-up. From these the mean and total FI for the life-course, and the step change in deficit accumulation from one time period to another was derived. Echocardiographic data at 60–64 years provided: ejection fraction (EF), left ventricular mass indexed to body surface area (LVmassi, BSA), myocardial contraction fraction indexed to BSA (MCFi) and E/e′. Generalized linear models assessed the association between FIs and echocardiographic parameters after adjustment for relevant covariates. 1375 participants were included. For each single new deficit accumulated at any one of the 4 time periods, LVmassi increased by 0.91–1.44% (p < 0.013), while MCFi decreased by 0.6–1.02% (p < 0.05). A unit increase in FI at age 45–54 and 60–64, decreased EF by 11–12% (p < 0.013). A single health deficit step change occurring between 60 and 64 years and one of the earlier time periods, translated into higher odds (2.1–78.5, p < 0.020) of elevated LV filling pressure. Thus, the accumulation of health deficits at any time period of the life-course associates with a maladaptive cardiac phenotype in older age, dominated by myocardial hypertrophy and poorer function.Constantin-Cristian TopriceanuJames C. MoonRebecca HardyNishi ChaturvediAlun D. HughesGabriella CapturNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Constantin-Cristian Topriceanu James C. Moon Rebecca Hardy Nishi Chaturvedi Alun D. Hughes Gabriella Captur Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function
description	Abstract A frailty index (FI) counts health deficit accumulation. Besides traditional risk factors, it is unknown whether the health deficit burden is related to the appearance of cardiovascular disease. In order to answer this question, the same multidimensional FI looking at 45-health deficits was serially calculated per participant at 4 time periods (0–16, 19–44, 45–54 and 60–64 years) using data from the 1946 Medical Research Council (MRC) British National Survey of Health and Development (NSHD)—the world’s longest running longitudinal birth cohort with continuous follow-up. From these the mean and total FI for the life-course, and the step change in deficit accumulation from one time period to another was derived. Echocardiographic data at 60–64 years provided: ejection fraction (EF), left ventricular mass indexed to body surface area (LVmassi, BSA), myocardial contraction fraction indexed to BSA (MCFi) and E/e′. Generalized linear models assessed the association between FIs and echocardiographic parameters after adjustment for relevant covariates. 1375 participants were included. For each single new deficit accumulated at any one of the 4 time periods, LVmassi increased by 0.91–1.44% (p < 0.013), while MCFi decreased by 0.6–1.02% (p < 0.05). A unit increase in FI at age 45–54 and 60–64, decreased EF by 11–12% (p < 0.013). A single health deficit step change occurring between 60 and 64 years and one of the earlier time periods, translated into higher odds (2.1–78.5, p < 0.020) of elevated LV filling pressure. Thus, the accumulation of health deficits at any time period of the life-course associates with a maladaptive cardiac phenotype in older age, dominated by myocardial hypertrophy and poorer function.
format	article
author	Constantin-Cristian Topriceanu James C. Moon Rebecca Hardy Nishi Chaturvedi Alun D. Hughes Gabriella Captur
author_facet	Constantin-Cristian Topriceanu James C. Moon Rebecca Hardy Nishi Chaturvedi Alun D. Hughes Gabriella Captur
author_sort	Constantin-Cristian Topriceanu
title	Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function
title_short	Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function
title_full	Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function
title_fullStr	Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function
title_full_unstemmed	Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function
title_sort	longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90af7d40e50b4543a8ebaa2bae94121b
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Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function

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