Placental response to maternal SARS-CoV-2 infection

Abstract The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of 66 COVID-19-positive women in late pregnancy, we...

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Autores principales:	Mirella Mourad, Taylor Jacob, Elena Sadovsky, Shai Bejerano, Glicella Salazar-De Simone, Tarique Rajasaheb Bagalkot, Jason Zucker, Michael T. Yin, Jennifer Y. Chang, Lihong Liu, Larisa Debelenko, Carrie J. Shawber, Morgan Firestein, Yingshi Ouyang, Cynthia Gyamfi-Bannerman, Anna Penn, Alexander Sorkin, Ronald Wapner, Yoel Sadovsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90b2da73fe7842b7ac25cfe6e96cbaef
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spelling	oai:doaj.org-article:90b2da73fe7842b7ac25cfe6e96cbaef2021-12-02T16:08:05ZPlacental response to maternal SARS-CoV-2 infection10.1038/s41598-021-93931-02045-2322https://doaj.org/article/90b2da73fe7842b7ac25cfe6e96cbaef2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93931-0https://doaj.org/toc/2045-2322Abstract The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of 66 COVID-19-positive women in late pregnancy, we correlated clinical parameters with disease severity, placental histopathology, and the expression of viral entry and Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None of the demographic parameters or placental histopathological characteristics were associated with disease severity. The fetal-maternal transfer ratio for IgG against the N or S viral proteins was commonly less than one, as recently reported. We found that the expression level of placental ACE2, but not TMPRSS2 or Furin, was higher in women with severe COVID-19. Placental expression of IFITM1 and IFITM3, which have been implicated in antiviral response, was higher in participants with severe disease. We also showed that IFITM3 protein expression, which localized to early and late endosomes, was enhanced in severe COVID-19. Our data suggest an association between disease severity and placental SARS-CoV-2 processing and antiviral pathways, implying a role for these proteins in placental response to SARS-CoV-2.Mirella MouradTaylor JacobElena SadovskyShai BejeranoGlicella Salazar-De SimoneTarique Rajasaheb BagalkotJason ZuckerMichael T. YinJennifer Y. ChangLihong LiuLarisa DebelenkoCarrie J. ShawberMorgan FiresteinYingshi OuyangCynthia Gyamfi-BannermanAnna PennAlexander SorkinRonald WapnerYoel SadovskyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mirella Mourad Taylor Jacob Elena Sadovsky Shai Bejerano Glicella Salazar-De Simone Tarique Rajasaheb Bagalkot Jason Zucker Michael T. Yin Jennifer Y. Chang Lihong Liu Larisa Debelenko Carrie J. Shawber Morgan Firestein Yingshi Ouyang Cynthia Gyamfi-Bannerman Anna Penn Alexander Sorkin Ronald Wapner Yoel Sadovsky Placental response to maternal SARS-CoV-2 infection
description	Abstract The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of 66 COVID-19-positive women in late pregnancy, we correlated clinical parameters with disease severity, placental histopathology, and the expression of viral entry and Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None of the demographic parameters or placental histopathological characteristics were associated with disease severity. The fetal-maternal transfer ratio for IgG against the N or S viral proteins was commonly less than one, as recently reported. We found that the expression level of placental ACE2, but not TMPRSS2 or Furin, was higher in women with severe COVID-19. Placental expression of IFITM1 and IFITM3, which have been implicated in antiviral response, was higher in participants with severe disease. We also showed that IFITM3 protein expression, which localized to early and late endosomes, was enhanced in severe COVID-19. Our data suggest an association between disease severity and placental SARS-CoV-2 processing and antiviral pathways, implying a role for these proteins in placental response to SARS-CoV-2.
format	article
author	Mirella Mourad Taylor Jacob Elena Sadovsky Shai Bejerano Glicella Salazar-De Simone Tarique Rajasaheb Bagalkot Jason Zucker Michael T. Yin Jennifer Y. Chang Lihong Liu Larisa Debelenko Carrie J. Shawber Morgan Firestein Yingshi Ouyang Cynthia Gyamfi-Bannerman Anna Penn Alexander Sorkin Ronald Wapner Yoel Sadovsky
author_facet	Mirella Mourad Taylor Jacob Elena Sadovsky Shai Bejerano Glicella Salazar-De Simone Tarique Rajasaheb Bagalkot Jason Zucker Michael T. Yin Jennifer Y. Chang Lihong Liu Larisa Debelenko Carrie J. Shawber Morgan Firestein Yingshi Ouyang Cynthia Gyamfi-Bannerman Anna Penn Alexander Sorkin Ronald Wapner Yoel Sadovsky
author_sort	Mirella Mourad
title	Placental response to maternal SARS-CoV-2 infection
title_short	Placental response to maternal SARS-CoV-2 infection
title_full	Placental response to maternal SARS-CoV-2 infection
title_fullStr	Placental response to maternal SARS-CoV-2 infection
title_full_unstemmed	Placental response to maternal SARS-CoV-2 infection
title_sort	placental response to maternal sars-cov-2 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90b2da73fe7842b7ac25cfe6e96cbaef
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Placental response to maternal SARS-CoV-2 infection

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