Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.
Staphylococcus aureus frequently invades the human bloodstream, leading to life threatening bacteremia and often secondary foci of infection. Failure of antibiotic therapy to eradicate infection is frequently described; in some cases associated with altered S. aureus antimicrobial resistance or the...
Guardado en:
Autores principales: | Wei Gao, Kyra Chua, John K Davies, Hayley J Newton, Torsten Seemann, Paul F Harrison, Natasha E Holmes, Hyun-Woo Rhee, Jong-In Hong, Elizabeth L Hartland, Timothy P Stinear, Benjamin P Howden |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
|
Materias: | |
Acceso en línea: | https://doaj.org/article/90b6344c0adf498d8ac1defd34ede21e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Comparative Transcriptomic and Functional Assessments of Linezolid-Responsive Small RNA Genes in <named-content content-type="genus-species">Staphylococcus aureus</named-content>
por: Wei Gao, et al.
Publicado: (2020) -
Correspondence: Spontaneous secondary mutations confound analysis of the essential two-component system WalKR in Staphylococcus aureus
por: Ian R. Monk, et al.
Publicado: (2017) -
Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR.
por: Benjamin P Howden, et al.
Publicado: (2011) -
Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.
por: Josep M Sierra, et al.
Publicado: (2013) -
COMPARISON OF IN-VITRO EFFICACY OF VANCOMYCIN, LINEZOLID AND DAPTOMYCIN AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
por: Maria Mushtaq Gill, et al.
Publicado: (2019)