Wnt activation as a therapeutic strategy in medulloblastoma

The Wnt molecular subgroup of medulloblastoma is associated with better prognosis than the other molecular subgroups. Here, the authors show that activating Wnt signaling impairs tumor development and improves survival in Group 3 and Group 4 medulloblastoma preclinical models.

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Autores principales:	Branavan Manoranjan, Chitra Venugopal, David Bakhshinyan, Ashley A. Adile, Laura Richards, Michelle M. Kameda-Smith, Owen Whitley, Anna Dvorkin-Gheva, Minomi Subapanditha, Neil Savage, Nazanin Tatari, Dillon McKenna, Blessing Bassey-Archibong, Neil Winegarden, Robin Hallett, John P. Provias, Blake Yarascavitch, Olufemi Ajani, Adam Fleming, Gary D. Bader, Trevor J. Pugh, Bradley W. Doble, Sheila K. Singh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90b86d3d0f9c41078f2e0a70337929d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:90b86d3d0f9c41078f2e0a70337929d52021-12-02T15:09:18ZWnt activation as a therapeutic strategy in medulloblastoma10.1038/s41467-020-17953-42041-1723https://doaj.org/article/90b86d3d0f9c41078f2e0a70337929d52020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17953-4https://doaj.org/toc/2041-1723The Wnt molecular subgroup of medulloblastoma is associated with better prognosis than the other molecular subgroups. Here, the authors show that activating Wnt signaling impairs tumor development and improves survival in Group 3 and Group 4 medulloblastoma preclinical models.Branavan ManoranjanChitra VenugopalDavid BakhshinyanAshley A. AdileLaura RichardsMichelle M. Kameda-SmithOwen WhitleyAnna Dvorkin-GhevaMinomi SubapandithaNeil SavageNazanin TatariDillon McKennaBlessing Bassey-ArchibongNeil WinegardenRobin HallettJohn P. ProviasBlake YarascavitchOlufemi AjaniAdam FlemingGary D. BaderTrevor J. PughBradley W. DobleSheila K. SinghNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Branavan Manoranjan Chitra Venugopal David Bakhshinyan Ashley A. Adile Laura Richards Michelle M. Kameda-Smith Owen Whitley Anna Dvorkin-Gheva Minomi Subapanditha Neil Savage Nazanin Tatari Dillon McKenna Blessing Bassey-Archibong Neil Winegarden Robin Hallett John P. Provias Blake Yarascavitch Olufemi Ajani Adam Fleming Gary D. Bader Trevor J. Pugh Bradley W. Doble Sheila K. Singh Wnt activation as a therapeutic strategy in medulloblastoma
description	The Wnt molecular subgroup of medulloblastoma is associated with better prognosis than the other molecular subgroups. Here, the authors show that activating Wnt signaling impairs tumor development and improves survival in Group 3 and Group 4 medulloblastoma preclinical models.
format	article
author	Branavan Manoranjan Chitra Venugopal David Bakhshinyan Ashley A. Adile Laura Richards Michelle M. Kameda-Smith Owen Whitley Anna Dvorkin-Gheva Minomi Subapanditha Neil Savage Nazanin Tatari Dillon McKenna Blessing Bassey-Archibong Neil Winegarden Robin Hallett John P. Provias Blake Yarascavitch Olufemi Ajani Adam Fleming Gary D. Bader Trevor J. Pugh Bradley W. Doble Sheila K. Singh
author_facet	Branavan Manoranjan Chitra Venugopal David Bakhshinyan Ashley A. Adile Laura Richards Michelle M. Kameda-Smith Owen Whitley Anna Dvorkin-Gheva Minomi Subapanditha Neil Savage Nazanin Tatari Dillon McKenna Blessing Bassey-Archibong Neil Winegarden Robin Hallett John P. Provias Blake Yarascavitch Olufemi Ajani Adam Fleming Gary D. Bader Trevor J. Pugh Bradley W. Doble Sheila K. Singh
author_sort	Branavan Manoranjan
title	Wnt activation as a therapeutic strategy in medulloblastoma
title_short	Wnt activation as a therapeutic strategy in medulloblastoma
title_full	Wnt activation as a therapeutic strategy in medulloblastoma
title_fullStr	Wnt activation as a therapeutic strategy in medulloblastoma
title_full_unstemmed	Wnt activation as a therapeutic strategy in medulloblastoma
title_sort	wnt activation as a therapeutic strategy in medulloblastoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/90b86d3d0f9c41078f2e0a70337929d5
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Wnt activation as a therapeutic strategy in medulloblastoma

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