Quantifying post-transcriptional regulation in the development of Drosophila melanogaster

Proteome and transcriptome often show poor correlation, hindering the system-wide analysis of post-transcriptional regulation. Here, the authors study proteome and transcriptome dynamics during Drosophila embryogenesis and present basic mathematical models describing the temporal regulation of most...

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Autores principales: Kolja Becker, Alina Bluhm, Nuria Casas-Vila, Nadja Dinges, Mario Dejung, Sergi Sayols, Clemens Kreutz, Jean-Yves Roignant, Falk Butter, Stefan Legewie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/90b8c01a01c74981a5040868dc210ebe
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Sumario:Proteome and transcriptome often show poor correlation, hindering the system-wide analysis of post-transcriptional regulation. Here, the authors study proteome and transcriptome dynamics during Drosophila embryogenesis and present basic mathematical models describing the temporal regulation of most protein-RNA pairs.