Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing

Omary Mzava,1 Zehra Tas,1 Kutay İçöz1,2 1BioMINDS (Bio Micro/Nano Devices and Sensors) Laboratory, Department of Electrical and Electronics Engineering, 2Bioengineering Department, Abdullah Gül University, Kayseri, Turkey Abstract: We report a time and cost efficient s...

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Autores principales:	Mzava O, Taş Z, İçöz K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	magnetic micro/nano particle accumulation signal amplification image based detection magnetic dipole-dipole interaction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/90bb47b9cad64a6197b3c634a23fd2ee
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spelling	oai:doaj.org-article:90bb47b9cad64a6197b3c634a23fd2ee2021-12-02T02:43:42ZMagnetic micro/nanoparticle flocculation-based signal amplification for biosensing1178-2013https://doaj.org/article/90bb47b9cad64a6197b3c634a23fd2ee2016-06-01T00:00:00Zhttps://www.dovepress.com/magnetic-micronanoparticle-flocculation-based-signal-amplification-for-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Omary Mzava,1 Zehra Tas,1 Kutay İçöz1,2 1BioMINDS (Bio Micro/Nano Devices and Sensors) Laboratory, Department of Electrical and Electronics Engineering, 2Bioengineering Department, Abdullah Gül University, Kayseri, Turkey Abstract: We report a time and cost efficient signal amplification method for biosensors employing magnetic particles. In this method, magnetic particles in an applied external magnetic field form magnetic dipoles, interact with each other, and accumulate along the magnetic field lines. This magnetic interaction does not need any biomolecular coating for binding and can be controlled with the strength of the applied magnetic field. The accumulation can be used to amplify the corresponding pixel area that is obtained from an image of a single magnetic particle. An application of the method to the Escherichia coli 0157:H7 bacteria samples is demonstrated in order to show the potential of the approach. A minimum of threefold to a maximum of 60-fold amplification is reached from a single bacteria cell under a magnetic field of 20 mT. Keywords: magnetic micro/nanoparticle accumulation, signal amplification, image-based detection, magnetic dipole–dipole interactionMzava OTaş Zİçöz KDove Medical Pressarticlemagnetic micro/nano particle accumulationsignal amplificationimage based detectionmagnetic dipole-dipole interactionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2619-2631 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic micro/nano particle accumulation signal amplification image based detection magnetic dipole-dipole interaction Medicine (General) R5-920
spellingShingle	magnetic micro/nano particle accumulation signal amplification image based detection magnetic dipole-dipole interaction Medicine (General) R5-920 Mzava O Taş Z İçöz K Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
description	Omary Mzava,1 Zehra Tas,1 Kutay İçöz1,2 1BioMINDS (Bio Micro/Nano Devices and Sensors) Laboratory, Department of Electrical and Electronics Engineering, 2Bioengineering Department, Abdullah Gül University, Kayseri, Turkey Abstract: We report a time and cost efficient signal amplification method for biosensors employing magnetic particles. In this method, magnetic particles in an applied external magnetic field form magnetic dipoles, interact with each other, and accumulate along the magnetic field lines. This magnetic interaction does not need any biomolecular coating for binding and can be controlled with the strength of the applied magnetic field. The accumulation can be used to amplify the corresponding pixel area that is obtained from an image of a single magnetic particle. An application of the method to the Escherichia coli 0157:H7 bacteria samples is demonstrated in order to show the potential of the approach. A minimum of threefold to a maximum of 60-fold amplification is reached from a single bacteria cell under a magnetic field of 20 mT. Keywords: magnetic micro/nanoparticle accumulation, signal amplification, image-based detection, magnetic dipole–dipole interaction
format	article
author	Mzava O Taş Z İçöz K
author_facet	Mzava O Taş Z İçöz K
author_sort	Mzava O
title	Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
title_short	Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
title_full	Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
title_fullStr	Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
title_full_unstemmed	Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
title_sort	magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/90bb47b9cad64a6197b3c634a23fd2ee
work_keys_str_mv	AT mzavao magneticmicronanoparticleflocculationbasedsignalamplificationforbiosensing AT tasz magneticmicronanoparticleflocculationbasedsignalamplificationforbiosensing AT icozk magneticmicronanoparticleflocculationbasedsignalamplificationforbiosensing
_version_	1718402234631323648

Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing

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