Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest

Abstract With NASA’s plans for the human exploration of Mars, astronauts will be exposed to mission durations much longer than current spaceflight missions on the International Space Station. These mission durations will increase the risk for circadian misalignment. Exercise has gained increasing in...

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Autores principales:	Stefan Mendt, Hanns-Christian Gunga, Dieter Felsenberg, Daniel L. Belavy, Mathias Steinach, Alexander C. Stahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/90bbde59b9c24ae5a74102c38dc9aae5
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spelling	oai:doaj.org-article:90bbde59b9c24ae5a74102c38dc9aae52021-12-02T15:07:21ZRegular exercise counteracts circadian shifts in core body temperature during long-duration bed rest10.1038/s41526-020-00129-12373-8065https://doaj.org/article/90bbde59b9c24ae5a74102c38dc9aae52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41526-020-00129-1https://doaj.org/toc/2373-8065Abstract With NASA’s plans for the human exploration of Mars, astronauts will be exposed to mission durations much longer than current spaceflight missions on the International Space Station. These mission durations will increase the risk for circadian misalignment. Exercise has gained increasing interest as a non-pharmacological aid to entrain the circadian system. To assess the potential of exercise as a countermeasure to mitigate the risk for circadian disorders during spaceflight, we investigated the effects of long-term head-down tilt bed rest (HDBR) with and without exercise on the circadian rhythm of core body temperature. Core body temperature was recorded for 24 h using a rectal probe in sixteen healthy men (age: 30.5 ± 7.5 years (mean ± SD)) after 7 days and 49 days of HDBR. Five participants underwent HDBR only (CTR), five participants underwent HDBR and performed resistive exercises (RE), and six participants underwent HDBR and performed resistive exercises superimposed with vibrations (RVE). The exercise was scheduled three times per week. CTR showed a phase delay of 0.69 h. In contrast, both exercise groups were characterized by a phase advance (0.45 h for RE and 0.45 h for RVE; p = 0.026 for interaction between time and group). These findings suggest that resistive exercise (with or without vibration) may also serve as a countermeasure during spaceflight to mitigate circadian misalignments. The results could also be important for increasing awareness about the role of circadian disorders in long-term bedridden patients.Stefan MendtHanns-Christian GungaDieter FelsenbergDaniel L. BelavyMathias SteinachAlexander C. StahnNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Stefan Mendt Hanns-Christian Gunga Dieter Felsenberg Daniel L. Belavy Mathias Steinach Alexander C. Stahn Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
description	Abstract With NASA’s plans for the human exploration of Mars, astronauts will be exposed to mission durations much longer than current spaceflight missions on the International Space Station. These mission durations will increase the risk for circadian misalignment. Exercise has gained increasing interest as a non-pharmacological aid to entrain the circadian system. To assess the potential of exercise as a countermeasure to mitigate the risk for circadian disorders during spaceflight, we investigated the effects of long-term head-down tilt bed rest (HDBR) with and without exercise on the circadian rhythm of core body temperature. Core body temperature was recorded for 24 h using a rectal probe in sixteen healthy men (age: 30.5 ± 7.5 years (mean ± SD)) after 7 days and 49 days of HDBR. Five participants underwent HDBR only (CTR), five participants underwent HDBR and performed resistive exercises (RE), and six participants underwent HDBR and performed resistive exercises superimposed with vibrations (RVE). The exercise was scheduled three times per week. CTR showed a phase delay of 0.69 h. In contrast, both exercise groups were characterized by a phase advance (0.45 h for RE and 0.45 h for RVE; p = 0.026 for interaction between time and group). These findings suggest that resistive exercise (with or without vibration) may also serve as a countermeasure during spaceflight to mitigate circadian misalignments. The results could also be important for increasing awareness about the role of circadian disorders in long-term bedridden patients.
format	article
author	Stefan Mendt Hanns-Christian Gunga Dieter Felsenberg Daniel L. Belavy Mathias Steinach Alexander C. Stahn
author_facet	Stefan Mendt Hanns-Christian Gunga Dieter Felsenberg Daniel L. Belavy Mathias Steinach Alexander C. Stahn
author_sort	Stefan Mendt
title	Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
title_short	Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
title_full	Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
title_fullStr	Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
title_full_unstemmed	Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
title_sort	regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90bbde59b9c24ae5a74102c38dc9aae5
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Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest

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