Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label

Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein interaction partners and crosslinking sites.

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Autores principales: Yi Yang, Haiping Song, Dan He, Shuai Zhang, Shizhong Dai, Shixian Lin, Rong Meng, Chu Wang, Peng R. Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/90bd7af9d1c84c018858e3904496dd5c
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spelling oai:doaj.org-article:90bd7af9d1c84c018858e3904496dd5c2021-12-02T16:49:40ZGenetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label10.1038/ncomms122992041-1723https://doaj.org/article/90bd7af9d1c84c018858e3904496dd5c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12299https://doaj.org/toc/2041-1723Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein interaction partners and crosslinking sites.Yi YangHaiping SongDan HeShuai ZhangShizhong DaiShixian LinRong MengChu WangPeng R. ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yi Yang
Haiping Song
Dan He
Shuai Zhang
Shizhong Dai
Shixian Lin
Rong Meng
Chu Wang
Peng R. Chen
Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
description Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein interaction partners and crosslinking sites.
format article
author Yi Yang
Haiping Song
Dan He
Shuai Zhang
Shizhong Dai
Shixian Lin
Rong Meng
Chu Wang
Peng R. Chen
author_facet Yi Yang
Haiping Song
Dan He
Shuai Zhang
Shizhong Dai
Shixian Lin
Rong Meng
Chu Wang
Peng R. Chen
author_sort Yi Yang
title Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
title_short Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
title_full Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
title_fullStr Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
title_full_unstemmed Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
title_sort genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/90bd7af9d1c84c018858e3904496dd5c
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