Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label
Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein interaction partners and crosslinking sites.
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Nature Portfolio
2016
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oai:doaj.org-article:90bd7af9d1c84c018858e3904496dd5c2021-12-02T16:49:40ZGenetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label10.1038/ncomms122992041-1723https://doaj.org/article/90bd7af9d1c84c018858e3904496dd5c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12299https://doaj.org/toc/2041-1723Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein interaction partners and crosslinking sites.Yi YangHaiping SongDan HeShuai ZhangShizhong DaiShixian LinRong MengChu WangPeng R. ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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Science Q Yi Yang Haiping Song Dan He Shuai Zhang Shizhong Dai Shixian Lin Rong Meng Chu Wang Peng R. Chen Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label |
description |
Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein interaction partners and crosslinking sites. |
format |
article |
author |
Yi Yang Haiping Song Dan He Shuai Zhang Shizhong Dai Shixian Lin Rong Meng Chu Wang Peng R. Chen |
author_facet |
Yi Yang Haiping Song Dan He Shuai Zhang Shizhong Dai Shixian Lin Rong Meng Chu Wang Peng R. Chen |
author_sort |
Yi Yang |
title |
Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label |
title_short |
Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label |
title_full |
Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label |
title_fullStr |
Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label |
title_full_unstemmed |
Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label |
title_sort |
genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/90bd7af9d1c84c018858e3904496dd5c |
work_keys_str_mv |
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1718383229547839488 |