Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Prostate-specific antigen is used as a biomarker of prostate cancer, but levels can be affected by other factors not related to cancer. Here, the authors find genes associated with prostate specific antigen levels in healthy men, which could be used to reduce over-diagnosis and over-treatment.

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Autores principales: Thomas J. Hoffmann, Michael N. Passarelli, Rebecca E. Graff, Nima C. Emami, Lori C. Sakoda, Eric Jorgenson, Laurel A. Habel, Jun Shan, Dilrini K. Ranatunga, Charles P. Quesenberry, Chun R. Chao, Nirupa R. Ghai, David Aaronson, Joseph Presti, Tobias Nordström, Zhaoming Wang, Sonja I. Berndt, Stephen J. Chanock, Jonathan D. Mosley, Robert J. Klein, Mridu Middha, Hans Lilja, Olle Melander, Mark N. Kvale, Pui-Yan Kwok, Catherine Schaefer, Neil Risch, Stephen K. Van Den Eeden, John S. Witte
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/90bfd13c12e74ae09f3017f178930048
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spelling oai:doaj.org-article:90bfd13c12e74ae09f3017f1789300482021-12-02T14:41:11ZGenome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer10.1038/ncomms142482041-1723https://doaj.org/article/90bfd13c12e74ae09f3017f1789300482017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14248https://doaj.org/toc/2041-1723Prostate-specific antigen is used as a biomarker of prostate cancer, but levels can be affected by other factors not related to cancer. Here, the authors find genes associated with prostate specific antigen levels in healthy men, which could be used to reduce over-diagnosis and over-treatment.Thomas J. HoffmannMichael N. PassarelliRebecca E. GraffNima C. EmamiLori C. SakodaEric JorgensonLaurel A. HabelJun ShanDilrini K. RanatungaCharles P. QuesenberryChun R. ChaoNirupa R. GhaiDavid AaronsonJoseph PrestiTobias NordströmZhaoming WangSonja I. BerndtStephen J. ChanockJonathan D. MosleyRobert J. KleinMridu MiddhaHans LiljaOlle MelanderMark N. KvalePui-Yan KwokCatherine SchaeferNeil RischStephen K. Van Den EedenJohn S. WitteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Thomas J. Hoffmann
Michael N. Passarelli
Rebecca E. Graff
Nima C. Emami
Lori C. Sakoda
Eric Jorgenson
Laurel A. Habel
Jun Shan
Dilrini K. Ranatunga
Charles P. Quesenberry
Chun R. Chao
Nirupa R. Ghai
David Aaronson
Joseph Presti
Tobias Nordström
Zhaoming Wang
Sonja I. Berndt
Stephen J. Chanock
Jonathan D. Mosley
Robert J. Klein
Mridu Middha
Hans Lilja
Olle Melander
Mark N. Kvale
Pui-Yan Kwok
Catherine Schaefer
Neil Risch
Stephen K. Van Den Eeden
John S. Witte
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
description Prostate-specific antigen is used as a biomarker of prostate cancer, but levels can be affected by other factors not related to cancer. Here, the authors find genes associated with prostate specific antigen levels in healthy men, which could be used to reduce over-diagnosis and over-treatment.
format article
author Thomas J. Hoffmann
Michael N. Passarelli
Rebecca E. Graff
Nima C. Emami
Lori C. Sakoda
Eric Jorgenson
Laurel A. Habel
Jun Shan
Dilrini K. Ranatunga
Charles P. Quesenberry
Chun R. Chao
Nirupa R. Ghai
David Aaronson
Joseph Presti
Tobias Nordström
Zhaoming Wang
Sonja I. Berndt
Stephen J. Chanock
Jonathan D. Mosley
Robert J. Klein
Mridu Middha
Hans Lilja
Olle Melander
Mark N. Kvale
Pui-Yan Kwok
Catherine Schaefer
Neil Risch
Stephen K. Van Den Eeden
John S. Witte
author_facet Thomas J. Hoffmann
Michael N. Passarelli
Rebecca E. Graff
Nima C. Emami
Lori C. Sakoda
Eric Jorgenson
Laurel A. Habel
Jun Shan
Dilrini K. Ranatunga
Charles P. Quesenberry
Chun R. Chao
Nirupa R. Ghai
David Aaronson
Joseph Presti
Tobias Nordström
Zhaoming Wang
Sonja I. Berndt
Stephen J. Chanock
Jonathan D. Mosley
Robert J. Klein
Mridu Middha
Hans Lilja
Olle Melander
Mark N. Kvale
Pui-Yan Kwok
Catherine Schaefer
Neil Risch
Stephen K. Van Den Eeden
John S. Witte
author_sort Thomas J. Hoffmann
title Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
title_short Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
title_full Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
title_fullStr Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
title_full_unstemmed Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
title_sort genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/90bfd13c12e74ae09f3017f178930048
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