A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19

A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19

Abstract The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases ha...

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Autores principales: Qiang Tang, Yanwei Liu, Yingfeng Fu, Ziyang Di, Kailiang Xu, Bo Tang, Hui Wu, Maojun Di
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/90c30a68d1954c19b2529fa5fd7159b3
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spelling oai:doaj.org-article:90c30a68d1954c19b2529fa5fd7159b32021-12-02T18:03:21ZA comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-1910.1038/s41598-021-87413-62045-2322https://doaj.org/article/90c30a68d1954c19b2529fa5fd7159b32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87413-6https://doaj.org/toc/2045-2322Abstract The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that advanced age, comorbidities, dyspnea, lymphopenia, and elevated levels of Fbg, CTnI, IL-6, and serum ferritin were significant predictors of disease aggravation. Further, we performed a Kaplan–Meier analysis to evaluate the prognosis of COVID-19 patients, which suggested that 64.9% of the patients had not experienced ICU transfers and survival from the hospital.Qiang TangYanwei LiuYingfeng FuZiyang DiKailiang XuBo TangHui WuMaojun DiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Qiang Tang
Yanwei Liu
Yingfeng Fu
Ziyang Di
Kailiang Xu
Bo Tang
Hui Wu
Maojun Di
A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19
description Abstract The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that advanced age, comorbidities, dyspnea, lymphopenia, and elevated levels of Fbg, CTnI, IL-6, and serum ferritin were significant predictors of disease aggravation. Further, we performed a Kaplan–Meier analysis to evaluate the prognosis of COVID-19 patients, which suggested that 64.9% of the patients had not experienced ICU transfers and survival from the hospital.
format article
author Qiang Tang
Yanwei Liu
Yingfeng Fu
Ziyang Di
Kailiang Xu
Bo Tang
Hui Wu
Maojun Di
author_facet Qiang Tang
Yanwei Liu
Yingfeng Fu
Ziyang Di
Kailiang Xu
Bo Tang
Hui Wu
Maojun Di
author_sort Qiang Tang
title A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19
title_short A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19
title_full A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19
title_fullStr A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19
title_full_unstemmed A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19
title_sort comprehensive evaluation of early potential risk factors for disease aggravation in patients with covid-19
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/90c30a68d1954c19b2529fa5fd7159b3
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