Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

The human shelterin complex protects telomere ends from being recognized as damaged DNA sites and regulates telomere length in conjunction with telomerase. Here the authors establish the stoichiometries of human shelterin complexes of various compositions and show shelterin provides dual pathways to...

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Autores principales: Ci Ji Lim, Arthur J. Zaug, Hee Jin Kim, Thomas R. Cech
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/90c4dc3412f446f394369937d6da4c33
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spelling oai:doaj.org-article:90c4dc3412f446f394369937d6da4c332021-12-02T17:06:10ZReconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity10.1038/s41467-017-01313-w2041-1723https://doaj.org/article/90c4dc3412f446f394369937d6da4c332017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01313-whttps://doaj.org/toc/2041-1723The human shelterin complex protects telomere ends from being recognized as damaged DNA sites and regulates telomere length in conjunction with telomerase. Here the authors establish the stoichiometries of human shelterin complexes of various compositions and show shelterin provides dual pathways to stimulate telomerase processivity.Ci Ji LimArthur J. ZaugHee Jin KimThomas R. CechNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ci Ji Lim
Arthur J. Zaug
Hee Jin Kim
Thomas R. Cech
Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
description The human shelterin complex protects telomere ends from being recognized as damaged DNA sites and regulates telomere length in conjunction with telomerase. Here the authors establish the stoichiometries of human shelterin complexes of various compositions and show shelterin provides dual pathways to stimulate telomerase processivity.
format article
author Ci Ji Lim
Arthur J. Zaug
Hee Jin Kim
Thomas R. Cech
author_facet Ci Ji Lim
Arthur J. Zaug
Hee Jin Kim
Thomas R. Cech
author_sort Ci Ji Lim
title Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
title_short Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
title_full Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
title_fullStr Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
title_full_unstemmed Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
title_sort reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/90c4dc3412f446f394369937d6da4c33
work_keys_str_mv AT cijilim reconstitutionofhumanshelterincomplexesrevealsunexpectedstoichiometryanddualpathwaystoenhancetelomeraseprocessivity
AT arthurjzaug reconstitutionofhumanshelterincomplexesrevealsunexpectedstoichiometryanddualpathwaystoenhancetelomeraseprocessivity
AT heejinkim reconstitutionofhumanshelterincomplexesrevealsunexpectedstoichiometryanddualpathwaystoenhancetelomeraseprocessivity
AT thomasrcech reconstitutionofhumanshelterincomplexesrevealsunexpectedstoichiometryanddualpathwaystoenhancetelomeraseprocessivity
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