Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy

Abstract We evaluated choroidal congestion using multimodal imaging in pachychoroid neovasculopathy (PNV). In a retrospective case series of 100 eyes of 99 treatment-naïve PNV patients, their clinical records were reviewed and the corresponding multimodal imaging studies were analyzed. We assessed a...

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Autores principales: Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Shoji Kishi, Hideo Akiyama
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/90c73ac661f94f25ab477f37c635bccd
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spelling oai:doaj.org-article:90c73ac661f94f25ab477f37c635bccd2021-12-02T15:08:10ZChronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy10.1038/s41598-021-95904-92045-2322https://doaj.org/article/90c73ac661f94f25ab477f37c635bccd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95904-9https://doaj.org/toc/2045-2322Abstract We evaluated choroidal congestion using multimodal imaging in pachychoroid neovasculopathy (PNV). In a retrospective case series of 100 eyes of 99 treatment-naïve PNV patients, their clinical records were reviewed and the corresponding multimodal imaging studies were analyzed. We assessed areas of choriocapillaris filling delay which overlapped with dilated outer choroidal vessels, choroidal neovascularization (CNV), and retinal pigment epithelium (RPE) atrophy. The study subjects were 78 men (78.8%) and 21 women (21.2%). The mean patient age was 67.5 ± 10.5 years. On indocyanine green angiography, all eyes showed choriocapillaris filling delay in the early phase. Dilated outer choroidal vessels were demonstrated in all eyes by en face optical coherence tomography. The areas of choriocapillaris filling delay overlapped extensively with that of dilated outer choroidal vessels. All eyes showed CNV localized within the sites of choriocapillaris filling delay. RPE atrophy was noted in 71 eyes (71.0%), and 68 of these (95.8%) had RPE atrophy within the areas showing choriocapillaris filling delay. These findings indicate that chronic choriocapillaris ischemia secondary to vortex vein congestion may lead to CNV development as well as RPE atrophy in eyes with PNV.Hidetaka MatsumotoJunki HoshinoRyo MukaiKosuke NakamuraShoji KishiHideo AkiyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hidetaka Matsumoto
Junki Hoshino
Ryo Mukai
Kosuke Nakamura
Shoji Kishi
Hideo Akiyama
Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy
description Abstract We evaluated choroidal congestion using multimodal imaging in pachychoroid neovasculopathy (PNV). In a retrospective case series of 100 eyes of 99 treatment-naïve PNV patients, their clinical records were reviewed and the corresponding multimodal imaging studies were analyzed. We assessed areas of choriocapillaris filling delay which overlapped with dilated outer choroidal vessels, choroidal neovascularization (CNV), and retinal pigment epithelium (RPE) atrophy. The study subjects were 78 men (78.8%) and 21 women (21.2%). The mean patient age was 67.5 ± 10.5 years. On indocyanine green angiography, all eyes showed choriocapillaris filling delay in the early phase. Dilated outer choroidal vessels were demonstrated in all eyes by en face optical coherence tomography. The areas of choriocapillaris filling delay overlapped extensively with that of dilated outer choroidal vessels. All eyes showed CNV localized within the sites of choriocapillaris filling delay. RPE atrophy was noted in 71 eyes (71.0%), and 68 of these (95.8%) had RPE atrophy within the areas showing choriocapillaris filling delay. These findings indicate that chronic choriocapillaris ischemia secondary to vortex vein congestion may lead to CNV development as well as RPE atrophy in eyes with PNV.
format article
author Hidetaka Matsumoto
Junki Hoshino
Ryo Mukai
Kosuke Nakamura
Shoji Kishi
Hideo Akiyama
author_facet Hidetaka Matsumoto
Junki Hoshino
Ryo Mukai
Kosuke Nakamura
Shoji Kishi
Hideo Akiyama
author_sort Hidetaka Matsumoto
title Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy
title_short Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy
title_full Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy
title_fullStr Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy
title_full_unstemmed Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy
title_sort chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/90c73ac661f94f25ab477f37c635bccd
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