Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs <italic toggle="yes">In Vivo</italic> and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism

Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs <italic toggle="yes">In Vivo</italic> and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism

ABSTRACT Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to differentiate along the myeloid lineage. In this study, we used an HSPC transplantation model to investigate the possible direct interaction of β-glucan and its receptor (dectin-1) on HSPCs in vivo. P...

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Autores principales: Cristina Bono, Alba Martínez, Javier Megías, Daniel Gozalbo, Alberto Yáñez, M. Luisa Gil
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
hematopoietic stem and progenitor cells
Candida albicans
dectin-1
TLR2
macrophages
trained immunity
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/90c81f4ab487455ba7308d7bcd3405ae
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