De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

In acute leukemia with KMT2A rearrangements (KMT2A-R), activating signaling mutations are common. Here, the authors use a retroviral acute myeloid mouse leukemia model to show that subclonal de novo activating mutations drive clonal evolution in acute leukemia with KMT2A-R and enhance clonal fitness...

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Autores principales:	Axel Hyrenius-Wittsten, Mattias Pilheden, Helena Sturesson, Jenny Hansson, Michael P. Walsh, Guangchun Song, Julhash U. Kazi, Jian Liu, Ramprasad Ramakrishan, Cristian Garcia-Ruiz, Stephanie Nance, Pankaj Gupta, Jinghui Zhang, Lars Rönnstrand, Anne Hultquist, James R. Downing, Karin Lindkvist-Petersson, Kajsa Paulsson, Marcus Järås, Tanja A. Gruber, Jing Ma, Anna K. Hagström-Andersson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90c8b9707fb44780aabe13e7a04984b5
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spelling	oai:doaj.org-article:90c8b9707fb44780aabe13e7a04984b52021-12-02T15:33:37ZDe novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia10.1038/s41467-018-04180-12041-1723https://doaj.org/article/90c8b9707fb44780aabe13e7a04984b52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04180-1https://doaj.org/toc/2041-1723In acute leukemia with KMT2A rearrangements (KMT2A-R), activating signaling mutations are common. Here, the authors use a retroviral acute myeloid mouse leukemia model to show that subclonal de novo activating mutations drive clonal evolution in acute leukemia with KMT2A-R and enhance clonal fitness.Axel Hyrenius-WittstenMattias PilhedenHelena SturessonJenny HanssonMichael P. WalshGuangchun SongJulhash U. KaziJian LiuRamprasad RamakrishanCristian Garcia-RuizStephanie NancePankaj GuptaJinghui ZhangLars RönnstrandAnne HultquistJames R. DowningKarin Lindkvist-PeterssonKajsa PaulssonMarcus JäråsTanja A. GruberJing MaAnna K. Hagström-AnderssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Axel Hyrenius-Wittsten Mattias Pilheden Helena Sturesson Jenny Hansson Michael P. Walsh Guangchun Song Julhash U. Kazi Jian Liu Ramprasad Ramakrishan Cristian Garcia-Ruiz Stephanie Nance Pankaj Gupta Jinghui Zhang Lars Rönnstrand Anne Hultquist James R. Downing Karin Lindkvist-Petersson Kajsa Paulsson Marcus Järås Tanja A. Gruber Jing Ma Anna K. Hagström-Andersson De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
description	In acute leukemia with KMT2A rearrangements (KMT2A-R), activating signaling mutations are common. Here, the authors use a retroviral acute myeloid mouse leukemia model to show that subclonal de novo activating mutations drive clonal evolution in acute leukemia with KMT2A-R and enhance clonal fitness.
format	article
author	Axel Hyrenius-Wittsten Mattias Pilheden Helena Sturesson Jenny Hansson Michael P. Walsh Guangchun Song Julhash U. Kazi Jian Liu Ramprasad Ramakrishan Cristian Garcia-Ruiz Stephanie Nance Pankaj Gupta Jinghui Zhang Lars Rönnstrand Anne Hultquist James R. Downing Karin Lindkvist-Petersson Kajsa Paulsson Marcus Järås Tanja A. Gruber Jing Ma Anna K. Hagström-Andersson
author_facet	Axel Hyrenius-Wittsten Mattias Pilheden Helena Sturesson Jenny Hansson Michael P. Walsh Guangchun Song Julhash U. Kazi Jian Liu Ramprasad Ramakrishan Cristian Garcia-Ruiz Stephanie Nance Pankaj Gupta Jinghui Zhang Lars Rönnstrand Anne Hultquist James R. Downing Karin Lindkvist-Petersson Kajsa Paulsson Marcus Järås Tanja A. Gruber Jing Ma Anna K. Hagström-Andersson
author_sort	Axel Hyrenius-Wittsten
title	De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
title_short	De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
title_full	De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
title_fullStr	De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
title_full_unstemmed	De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
title_sort	de novo activating mutations drive clonal evolution and enhance clonal fitness in kmt2a-rearranged leukemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/90c8b9707fb44780aabe13e7a04984b5
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De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

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