Broken sleep predicts hardened blood vessels.

Why does poor-quality sleep lead to atherosclerosis? In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when other common r...

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Autores principales:	Raphael Vallat, Vyoma D Shah, Susan Redline, Peter Attia, Matthew P Walker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/90cf0c61615445aeb840f74579f87ba1
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spelling	oai:doaj.org-article:90cf0c61615445aeb840f74579f87ba12021-12-02T19:54:28ZBroken sleep predicts hardened blood vessels.1544-91731545-788510.1371/journal.pbio.3000726https://doaj.org/article/90cf0c61615445aeb840f74579f87ba12020-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3000726https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Why does poor-quality sleep lead to atherosclerosis? In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when other common risk factors have been accounted for. Improving sleep quality may thus represent one preventive strategy for lowering inflammatory status and thus atherosclerosis risk, reinforcing public health policies focused on sleep health.Raphael VallatVyoma D ShahSusan RedlinePeter AttiaMatthew P WalkerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 18, Iss 6, p e3000726 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Raphael Vallat Vyoma D Shah Susan Redline Peter Attia Matthew P Walker Broken sleep predicts hardened blood vessels.
description	Why does poor-quality sleep lead to atherosclerosis? In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when other common risk factors have been accounted for. Improving sleep quality may thus represent one preventive strategy for lowering inflammatory status and thus atherosclerosis risk, reinforcing public health policies focused on sleep health.
format	article
author	Raphael Vallat Vyoma D Shah Susan Redline Peter Attia Matthew P Walker
author_facet	Raphael Vallat Vyoma D Shah Susan Redline Peter Attia Matthew P Walker
author_sort	Raphael Vallat
title	Broken sleep predicts hardened blood vessels.
title_short	Broken sleep predicts hardened blood vessels.
title_full	Broken sleep predicts hardened blood vessels.
title_fullStr	Broken sleep predicts hardened blood vessels.
title_full_unstemmed	Broken sleep predicts hardened blood vessels.
title_sort	broken sleep predicts hardened blood vessels.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/90cf0c61615445aeb840f74579f87ba1
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Broken sleep predicts hardened blood vessels.

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