Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study

Abstract Our aim was to evaluate maternal use of sedative drugs before, during, and after pregnancy and to assess the influence of use of these drugs on pregnancy outcomes. The study cohort (N = 6231) consists of all primiparous women, who lived in the city of Vantaa, Finland, and who delivered a si...

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Autores principales:	Satu-Maarit Björkstedt, Hannu Kautiainen, Ulla Tuomi, Mika Gissler, Pirjo Pennanen, Johan G. Eriksson, Merja K. Laine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90d6ee2fa10140bebf623f24e1d75069
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spelling	oai:doaj.org-article:90d6ee2fa10140bebf623f24e1d750692021-12-02T15:53:03ZMaternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study10.1038/s41598-021-84151-72045-2322https://doaj.org/article/90d6ee2fa10140bebf623f24e1d750692021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84151-7https://doaj.org/toc/2045-2322Abstract Our aim was to evaluate maternal use of sedative drugs before, during, and after pregnancy and to assess the influence of use of these drugs on pregnancy outcomes. The study cohort (N = 6231) consists of all primiparous women, who lived in the city of Vantaa, Finland, and who delivered a singleton between 2009 and 2015. Data were obtained from Finnish national health registers. Of the women, 3.2% (n = 202) purchased at least once sedative drugs within 90 days before conception, during pregnancy and/or within 90 days after delivery. Sedative drug users were older, less likely to cohabitate, more often smokers, had lower educational attainment and had more mental diseases (for all p < 0.001) compared with non-users. Sedative drug users purchased more often antidepressants and drugs for the alimentary tract, musculoskeletal and nervous system than non-users (for all p < 0.001). No adverse birth or pregnancy outcomes were found in the group using sedative drugs compared with the non-users. Studies in larger cohorts are needed to confirm our study findings.Satu-Maarit BjörkstedtHannu KautiainenUlla TuomiMika GisslerPirjo PennanenJohan G. ErikssonMerja K. LaineNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Satu-Maarit Björkstedt Hannu Kautiainen Ulla Tuomi Mika Gissler Pirjo Pennanen Johan G. Eriksson Merja K. Laine Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study
description	Abstract Our aim was to evaluate maternal use of sedative drugs before, during, and after pregnancy and to assess the influence of use of these drugs on pregnancy outcomes. The study cohort (N = 6231) consists of all primiparous women, who lived in the city of Vantaa, Finland, and who delivered a singleton between 2009 and 2015. Data were obtained from Finnish national health registers. Of the women, 3.2% (n = 202) purchased at least once sedative drugs within 90 days before conception, during pregnancy and/or within 90 days after delivery. Sedative drug users were older, less likely to cohabitate, more often smokers, had lower educational attainment and had more mental diseases (for all p < 0.001) compared with non-users. Sedative drug users purchased more often antidepressants and drugs for the alimentary tract, musculoskeletal and nervous system than non-users (for all p < 0.001). No adverse birth or pregnancy outcomes were found in the group using sedative drugs compared with the non-users. Studies in larger cohorts are needed to confirm our study findings.
format	article
author	Satu-Maarit Björkstedt Hannu Kautiainen Ulla Tuomi Mika Gissler Pirjo Pennanen Johan G. Eriksson Merja K. Laine
author_facet	Satu-Maarit Björkstedt Hannu Kautiainen Ulla Tuomi Mika Gissler Pirjo Pennanen Johan G. Eriksson Merja K. Laine
author_sort	Satu-Maarit Björkstedt
title	Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study
title_short	Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study
title_full	Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study
title_fullStr	Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study
title_full_unstemmed	Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study
title_sort	maternal use of sedative drugs and its effects on pregnancy outcomes: a finnish birth cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90d6ee2fa10140bebf623f24e1d75069
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Maternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study

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