Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts
Abstract Current research regarding the association between body mass index (BMI) and altered clinical outcomes of sepsis in Asian populations is insufficient. We investigated the association between BMI and clinical outcomes using two Japanese cohorts of severe sepsis (derivation cohort, Chiba Univ...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/90d8be6e2a994994a9e26f2d9559b400 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:90d8be6e2a994994a9e26f2d9559b400 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:90d8be6e2a994994a9e26f2d9559b4002021-12-02T15:23:07ZAssociation between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts10.1038/s41598-020-80284-32045-2322https://doaj.org/article/90d8be6e2a994994a9e26f2d9559b4002021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80284-3https://doaj.org/toc/2045-2322Abstract Current research regarding the association between body mass index (BMI) and altered clinical outcomes of sepsis in Asian populations is insufficient. We investigated the association between BMI and clinical outcomes using two Japanese cohorts of severe sepsis (derivation cohort, Chiba University Hospital, n = 614; validation cohort, multicenter cohort, n = 1561). Participants were categorized into the underweight (BMI < 18.5) and non-underweight (BMI ≥ 18.5) groups. The primary outcome was 28-day mortality. Univariate analysis of the derivation cohort indicated increased 28-day mortality trend in the underweight group compared to the non-underweight group (underweight 24.4% [20/82 cases] vs. non-underweight 16.0% [85/532 cases]; p = 0.060). In the primary analysis, multivariate analysis adjusted for baseline imbalance revealed that patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p = 0.031, adjusted odds ratio [OR] 1.91, 95% confidence interval [CI] 1.06–3.46). In a repeated analysis using a multicenter validation cohort (underweight n = 343, non-underweight n = 1218), patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p = 0.045, OR 1.40, 95% CI 1.00–1.97). In conclusion, patients with a BMI < 18.5 had a significantly increased 28-day mortality compared to those with a BMI ≥ 18.5 in Japanese cohorts with severe sepsis.Takehiko OamiSatoshi KarasawaTadanaga ShimadaTaka-aki NakadaToshikazu AbeHiroshi OguraAtsushi ShiraishiShigeki KushimotoDaizoh SaitohSeitaro FujishimaToshihiko MayumiYasukazu ShiinoTakehiko TaruiToru HifumiYasuhiro OtomoKohji OkamotoYutaka UmemuraJoji KotaniYuichiro SakamotoJunichi SasakiShin-ichiro ShiraishiKiyotsugu TakumaRyosuke TsurutaAkiyoshi HagiwaraKazuma YamakawaTomohiko MasunoNaoshi TakeyamaNorio YamashitaHiroto IkedaMasashi UeyamaSatoshi FujimiSatoshi GandoJAAM FORECAST GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Takehiko Oami Satoshi Karasawa Tadanaga Shimada Taka-aki Nakada Toshikazu Abe Hiroshi Ogura Atsushi Shiraishi Shigeki Kushimoto Daizoh Saitoh Seitaro Fujishima Toshihiko Mayumi Yasukazu Shiino Takehiko Tarui Toru Hifumi Yasuhiro Otomo Kohji Okamoto Yutaka Umemura Joji Kotani Yuichiro Sakamoto Junichi Sasaki Shin-ichiro Shiraishi Kiyotsugu Takuma Ryosuke Tsuruta Akiyoshi Hagiwara Kazuma Yamakawa Tomohiko Masuno Naoshi Takeyama Norio Yamashita Hiroto Ikeda Masashi Ueyama Satoshi Fujimi Satoshi Gando JAAM FORECAST Group Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts |
| description |
Abstract Current research regarding the association between body mass index (BMI) and altered clinical outcomes of sepsis in Asian populations is insufficient. We investigated the association between BMI and clinical outcomes using two Japanese cohorts of severe sepsis (derivation cohort, Chiba University Hospital, n = 614; validation cohort, multicenter cohort, n = 1561). Participants were categorized into the underweight (BMI < 18.5) and non-underweight (BMI ≥ 18.5) groups. The primary outcome was 28-day mortality. Univariate analysis of the derivation cohort indicated increased 28-day mortality trend in the underweight group compared to the non-underweight group (underweight 24.4% [20/82 cases] vs. non-underweight 16.0% [85/532 cases]; p = 0.060). In the primary analysis, multivariate analysis adjusted for baseline imbalance revealed that patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p = 0.031, adjusted odds ratio [OR] 1.91, 95% confidence interval [CI] 1.06–3.46). In a repeated analysis using a multicenter validation cohort (underweight n = 343, non-underweight n = 1218), patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p = 0.045, OR 1.40, 95% CI 1.00–1.97). In conclusion, patients with a BMI < 18.5 had a significantly increased 28-day mortality compared to those with a BMI ≥ 18.5 in Japanese cohorts with severe sepsis. |
| format |
article |
| author |
Takehiko Oami Satoshi Karasawa Tadanaga Shimada Taka-aki Nakada Toshikazu Abe Hiroshi Ogura Atsushi Shiraishi Shigeki Kushimoto Daizoh Saitoh Seitaro Fujishima Toshihiko Mayumi Yasukazu Shiino Takehiko Tarui Toru Hifumi Yasuhiro Otomo Kohji Okamoto Yutaka Umemura Joji Kotani Yuichiro Sakamoto Junichi Sasaki Shin-ichiro Shiraishi Kiyotsugu Takuma Ryosuke Tsuruta Akiyoshi Hagiwara Kazuma Yamakawa Tomohiko Masuno Naoshi Takeyama Norio Yamashita Hiroto Ikeda Masashi Ueyama Satoshi Fujimi Satoshi Gando JAAM FORECAST Group |
| author_facet |
Takehiko Oami Satoshi Karasawa Tadanaga Shimada Taka-aki Nakada Toshikazu Abe Hiroshi Ogura Atsushi Shiraishi Shigeki Kushimoto Daizoh Saitoh Seitaro Fujishima Toshihiko Mayumi Yasukazu Shiino Takehiko Tarui Toru Hifumi Yasuhiro Otomo Kohji Okamoto Yutaka Umemura Joji Kotani Yuichiro Sakamoto Junichi Sasaki Shin-ichiro Shiraishi Kiyotsugu Takuma Ryosuke Tsuruta Akiyoshi Hagiwara Kazuma Yamakawa Tomohiko Masuno Naoshi Takeyama Norio Yamashita Hiroto Ikeda Masashi Ueyama Satoshi Fujimi Satoshi Gando JAAM FORECAST Group |
| author_sort |
Takehiko Oami |
| title |
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts |
| title_short |
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts |
| title_full |
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts |
| title_fullStr |
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts |
| title_full_unstemmed |
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts |
| title_sort |
association between low body mass index and increased 28-day mortality of severe sepsis in japanese cohorts |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/90d8be6e2a994994a9e26f2d9559b400 |
| work_keys_str_mv |
AT takehikooami associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT satoshikarasawa associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT tadanagashimada associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT takaakinakada associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT toshikazuabe associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT hiroshiogura associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT atsushishiraishi associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT shigekikushimoto associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT daizohsaitoh associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT seitarofujishima associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT toshihikomayumi associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT yasukazushiino associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT takehikotarui associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT toruhifumi associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT yasuhirootomo associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT kohjiokamoto associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT yutakaumemura associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT jojikotani associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT yuichirosakamoto associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT junichisasaki associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT shinichiroshiraishi associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT kiyotsugutakuma associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT ryosuketsuruta associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT akiyoshihagiwara associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT kazumayamakawa associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT tomohikomasuno associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT naoshitakeyama associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT norioyamashita associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT hirotoikeda associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT masashiueyama associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT satoshifujimi associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT satoshigando associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts AT jaamforecastgroup associationbetweenlowbodymassindexandincreased28daymortalityofseveresepsisinjapanesecohorts |
| _version_ |
1718387338820714496 |