Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions

Background. Cancer stem cells (CSC) and their role in tumorigenesis of various solid tumors have been studied in past decades. Urothelial CSC were first identified 10 years ago and subsequent studies have been performed with the aim to identify reliable markers of CSC. So far, a few studies have inv...

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Autores principales:	Jaromir Hacek, Antonin Brisuda, Marek Babjuk, Josef Zamecnik
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	cancer stem cells immunohistochemistry markers urothelial carcinoma Medicine R
Acceso en línea:	https://doaj.org/article/90dabc386d9d444f83bcd2a84f4b02cc
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spelling	oai:doaj.org-article:90dabc386d9d444f83bcd2a84f4b02cc2021-11-29T08:47:12ZExpression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions1213-81181804-752110.5507/bp.2020.017https://doaj.org/article/90dabc386d9d444f83bcd2a84f4b02cc2021-09-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202103-0012_expression-of-cancer-stem-cells-markers-in-urinary-bladder-urothelial-carcinoma-and-its-precursor-lesions.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Background. Cancer stem cells (CSC) and their role in tumorigenesis of various solid tumors have been studied in past decades. Urothelial CSC were first identified 10 years ago and subsequent studies have been performed with the aim to identify reliable markers of CSC. So far, a few studies have investigated a relationship between CSC markers expression in urothelial carcinoma tissue and histopathological characteristics of the tumor. Methods. In our study, we evaluated an immunoexpression of the CSC markers CD24, CD44, CD66 and CD133 in tissue sections of urothelial carcinoma (all tumor grades and stages were included), urothelial carcinoma in situ and non-neoplastic urothelium, totally 218 specimens were enrolled. Results. All studied molecules were expressed either in tumor tissue and non-neoplastic urothelium. Urothelial carcinomas of higher tumor grade and stage expressed molecules CD24 and CD133 significantly more frequently whereas molecules CD44 and CD66 did not show significant association with tumor histopathological features. Conclusions. Our results showed that studied molecules are not suitable for direct detection of CSC in urothelial carcinoma tissue sections, but an expression of molecules CD24 and CD133 is significantly related to urothelial carcinoma grade and stage, which are both important prognostic indicators and therefore an expression of these markers might have a potential prognostic value.Jaromir HacekAntonin BrisudaMarek BabjukJosef ZamecnikPalacký University Olomouc, Faculty of Medicine and Dentistryarticlecancer stem cellsimmunohistochemistrymarkersurothelial carcinomaMedicineRENBiomedical Papers, Vol 165, Iss 3, Pp 316-321 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer stem cells immunohistochemistry markers urothelial carcinoma Medicine R
spellingShingle	cancer stem cells immunohistochemistry markers urothelial carcinoma Medicine R Jaromir Hacek Antonin Brisuda Marek Babjuk Josef Zamecnik Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions
description	Background. Cancer stem cells (CSC) and their role in tumorigenesis of various solid tumors have been studied in past decades. Urothelial CSC were first identified 10 years ago and subsequent studies have been performed with the aim to identify reliable markers of CSC. So far, a few studies have investigated a relationship between CSC markers expression in urothelial carcinoma tissue and histopathological characteristics of the tumor. Methods. In our study, we evaluated an immunoexpression of the CSC markers CD24, CD44, CD66 and CD133 in tissue sections of urothelial carcinoma (all tumor grades and stages were included), urothelial carcinoma in situ and non-neoplastic urothelium, totally 218 specimens were enrolled. Results. All studied molecules were expressed either in tumor tissue and non-neoplastic urothelium. Urothelial carcinomas of higher tumor grade and stage expressed molecules CD24 and CD133 significantly more frequently whereas molecules CD44 and CD66 did not show significant association with tumor histopathological features. Conclusions. Our results showed that studied molecules are not suitable for direct detection of CSC in urothelial carcinoma tissue sections, but an expression of molecules CD24 and CD133 is significantly related to urothelial carcinoma grade and stage, which are both important prognostic indicators and therefore an expression of these markers might have a potential prognostic value.
format	article
author	Jaromir Hacek Antonin Brisuda Marek Babjuk Josef Zamecnik
author_facet	Jaromir Hacek Antonin Brisuda Marek Babjuk Josef Zamecnik
author_sort	Jaromir Hacek
title	Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions
title_short	Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions
title_full	Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions
title_fullStr	Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions
title_full_unstemmed	Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions
title_sort	expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/90dabc386d9d444f83bcd2a84f4b02cc
work_keys_str_mv	AT jaromirhacek expressionofcancerstemcellsmarkersinurinarybladderurothelialcarcinomaanditsprecursorlesions AT antoninbrisuda expressionofcancerstemcellsmarkersinurinarybladderurothelialcarcinomaanditsprecursorlesions AT marekbabjuk expressionofcancerstemcellsmarkersinurinarybladderurothelialcarcinomaanditsprecursorlesions AT josefzamecnik expressionofcancerstemcellsmarkersinurinarybladderurothelialcarcinomaanditsprecursorlesions
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Expression of cancer stem cells markers in urinary bladder urothelial carcinoma and its precursor lesions

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