The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
α-Synuclein is a presynaptic protein whose aberrant aggregation is associated with Parkinson’s disease. Here, the authors show how αSynuclein-induced docking of synaptic vesicles is modulated by the lipid composition changes typically observed in neurodegeneration using an in vitro system.
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Nature Portfolio
2021
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oai:doaj.org-article:90db4d5570b44c19b3ebf52d3e73f49f2021-12-02T14:26:52ZThe docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition10.1038/s41467-021-21027-42041-1723https://doaj.org/article/90db4d5570b44c19b3ebf52d3e73f49f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21027-4https://doaj.org/toc/2041-1723α-Synuclein is a presynaptic protein whose aberrant aggregation is associated with Parkinson’s disease. Here, the authors show how αSynuclein-induced docking of synaptic vesicles is modulated by the lipid composition changes typically observed in neurodegeneration using an in vitro system.Wing K. ManBogachan TahirbegiMichail D. VrettasSwapan PreetLiming YingMichele VendruscoloAlfonso De SimoneGiuliana FuscoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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Science Q Wing K. Man Bogachan Tahirbegi Michail D. Vrettas Swapan Preet Liming Ying Michele Vendruscolo Alfonso De Simone Giuliana Fusco The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition |
| description |
α-Synuclein is a presynaptic protein whose aberrant aggregation is associated with Parkinson’s disease. Here, the authors show how αSynuclein-induced docking of synaptic vesicles is modulated by the lipid composition changes typically observed in neurodegeneration using an in vitro system. |
| format |
article |
| author |
Wing K. Man Bogachan Tahirbegi Michail D. Vrettas Swapan Preet Liming Ying Michele Vendruscolo Alfonso De Simone Giuliana Fusco |
| author_facet |
Wing K. Man Bogachan Tahirbegi Michail D. Vrettas Swapan Preet Liming Ying Michele Vendruscolo Alfonso De Simone Giuliana Fusco |
| author_sort |
Wing K. Man |
| title |
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition |
| title_short |
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition |
| title_full |
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition |
| title_fullStr |
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition |
| title_full_unstemmed |
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition |
| title_sort |
docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/90db4d5570b44c19b3ebf52d3e73f49f |
| work_keys_str_mv |
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