Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy

Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane-bound enzyme best known for its function in the brain, but also linked to cancer progression. Here, the authors show that MAO-A is expressed in tumor associated macrophages, promoting their immunosuppressive properties, and that MAO inhi...

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Autores principales:	Yu-Chen Wang, Xi Wang, Jiaji Yu, Feiyang Ma, Zhe Li, Yang Zhou, Samuel Zeng, Xiaoya Ma, Yan-Ruide Li, Adam Neal, Jie Huang, Angela To, Nicole Clarke, Sanaz Memarzadeh, Matteo Pellegrini, Lili Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90dbc47fa143484c89dae7f6960677f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:90dbc47fa143484c89dae7f6960677f02021-12-02T17:30:39ZTargeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy10.1038/s41467-021-23164-22041-1723https://doaj.org/article/90dbc47fa143484c89dae7f6960677f02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23164-2https://doaj.org/toc/2041-1723Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane-bound enzyme best known for its function in the brain, but also linked to cancer progression. Here, the authors show that MAO-A is expressed in tumor associated macrophages, promoting their immunosuppressive properties, and that MAO inhibition suppresses tumor growth in preclinical models.Yu-Chen WangXi WangJiaji YuFeiyang MaZhe LiYang ZhouSamuel ZengXiaoya MaYan-Ruide LiAdam NealJie HuangAngela ToNicole ClarkeSanaz MemarzadehMatteo PellegriniLili YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Chen Wang Xi Wang Jiaji Yu Feiyang Ma Zhe Li Yang Zhou Samuel Zeng Xiaoya Ma Yan-Ruide Li Adam Neal Jie Huang Angela To Nicole Clarke Sanaz Memarzadeh Matteo Pellegrini Lili Yang Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
description	Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane-bound enzyme best known for its function in the brain, but also linked to cancer progression. Here, the authors show that MAO-A is expressed in tumor associated macrophages, promoting their immunosuppressive properties, and that MAO inhibition suppresses tumor growth in preclinical models.
format	article
author	Yu-Chen Wang Xi Wang Jiaji Yu Feiyang Ma Zhe Li Yang Zhou Samuel Zeng Xiaoya Ma Yan-Ruide Li Adam Neal Jie Huang Angela To Nicole Clarke Sanaz Memarzadeh Matteo Pellegrini Lili Yang
author_facet	Yu-Chen Wang Xi Wang Jiaji Yu Feiyang Ma Zhe Li Yang Zhou Samuel Zeng Xiaoya Ma Yan-Ruide Li Adam Neal Jie Huang Angela To Nicole Clarke Sanaz Memarzadeh Matteo Pellegrini Lili Yang
author_sort	Yu-Chen Wang
title	Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
title_short	Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
title_full	Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
title_fullStr	Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
title_full_unstemmed	Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy
title_sort	targeting monoamine oxidase a-regulated tumor-associated macrophage polarization for cancer immunotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90dbc47fa143484c89dae7f6960677f0
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Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy

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