Changes in energy metabolism and respiration in different tracheal narrowing in rats

Abstract Why obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that p...

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Autores principales:	Yael Segev, Haiat Nujedat, Eden Arazi, Mohammad H. Assadi, Ariel Tarasiuk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90df6e12cd5b4ddeb356972aa1d03985
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spelling	oai:doaj.org-article:90df6e12cd5b4ddeb356972aa1d039852021-12-02T19:16:54ZChanges in energy metabolism and respiration in different tracheal narrowing in rats10.1038/s41598-021-98799-82045-2322https://doaj.org/article/90df6e12cd5b4ddeb356972aa1d039852021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98799-8https://doaj.org/toc/2045-2322Abstract Why obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that persists following successful obstruction removal. Here, we explored the effect of two different types of tracheal narrowing, i.e., AO and mild airway obstruction (mAO), and its removal on respiratory homeostasis and metabolic physiology. We show that after ten weeks, mAO vs. AO consumes sufficient energy that is required to maintain respiratory homeostasis and thermoregulation. Obstruction removal was associated with largely irreversible increased feeding associated with elevated serum ghrelin, hypothalamic growth hormone secretagogue receptor 1a, and a phosphorylated Akt/Akt ratio, despite normalization of breathing and energy requirements. Our study supports the need for lifestyle eating behavior management, in addition to endocrine support, in order to attain healthy metabolic physiology in OSA patients.Yael SegevHaiat NujedatEden AraziMohammad H. AssadiAriel TarasiukNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yael Segev Haiat Nujedat Eden Arazi Mohammad H. Assadi Ariel Tarasiuk Changes in energy metabolism and respiration in different tracheal narrowing in rats
description	Abstract Why obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that persists following successful obstruction removal. Here, we explored the effect of two different types of tracheal narrowing, i.e., AO and mild airway obstruction (mAO), and its removal on respiratory homeostasis and metabolic physiology. We show that after ten weeks, mAO vs. AO consumes sufficient energy that is required to maintain respiratory homeostasis and thermoregulation. Obstruction removal was associated with largely irreversible increased feeding associated with elevated serum ghrelin, hypothalamic growth hormone secretagogue receptor 1a, and a phosphorylated Akt/Akt ratio, despite normalization of breathing and energy requirements. Our study supports the need for lifestyle eating behavior management, in addition to endocrine support, in order to attain healthy metabolic physiology in OSA patients.
format	article
author	Yael Segev Haiat Nujedat Eden Arazi Mohammad H. Assadi Ariel Tarasiuk
author_facet	Yael Segev Haiat Nujedat Eden Arazi Mohammad H. Assadi Ariel Tarasiuk
author_sort	Yael Segev
title	Changes in energy metabolism and respiration in different tracheal narrowing in rats
title_short	Changes in energy metabolism and respiration in different tracheal narrowing in rats
title_full	Changes in energy metabolism and respiration in different tracheal narrowing in rats
title_fullStr	Changes in energy metabolism and respiration in different tracheal narrowing in rats
title_full_unstemmed	Changes in energy metabolism and respiration in different tracheal narrowing in rats
title_sort	changes in energy metabolism and respiration in different tracheal narrowing in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90df6e12cd5b4ddeb356972aa1d03985
work_keys_str_mv	AT yaelsegev changesinenergymetabolismandrespirationindifferenttrachealnarrowinginrats AT haiatnujedat changesinenergymetabolismandrespirationindifferenttrachealnarrowinginrats AT edenarazi changesinenergymetabolismandrespirationindifferenttrachealnarrowinginrats AT mohammadhassadi changesinenergymetabolismandrespirationindifferenttrachealnarrowinginrats AT arieltarasiuk changesinenergymetabolismandrespirationindifferenttrachealnarrowinginrats
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Changes in energy metabolism and respiration in different tracheal narrowing in rats

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