Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan.
Colonic diverticula are located predominantly on the right side in Asia and on the left side in Europe and the United States. Factors associated with uncomplicated colonic diverticulosis and its distribution pattern have been unknown. Our aims are to investigate the prevalence and risk factors for u...
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2013
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oai:doaj.org-article:90e2763f401d41208a2c8b856fc2b8fa2021-11-18T08:42:45ZAlcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan.1932-620310.1371/journal.pone.0081137https://doaj.org/article/90e2763f401d41208a2c8b856fc2b8fa2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24339905/?tool=EBIhttps://doaj.org/toc/1932-6203Colonic diverticula are located predominantly on the right side in Asia and on the left side in Europe and the United States. Factors associated with uncomplicated colonic diverticulosis and its distribution pattern have been unknown. Our aims are to investigate the prevalence and risk factors for uncomplicated colonic diverticulosis. We conducted a prospective cross-sectional study in adults who underwent colonoscopy. Alcohol, alcohol related flushing, smoking, medications, and comorbidities were assessed by interview on the colonoscopy day. Alcohol consumption was categorized as nondrinker, light (1-180 g/week), moderate (181-360 g/week), and heavy (≥361 g/week). Smoking index was defined as the number of cigarettes per day multiplied by the number of smoking years and categorized as nonsmoker, <400, 400-799, and ≥800. A total of 2,164 consecutive patients were enrolled. Overall, 542 patients (25.1%) had uncomplicated colonic diverticulosis located on the right side (50%), bilaterally (29%), and on the left side (21%). Univariate analysis revealed age, male, smoking index, alcohol consumption, aspirin use, anticoagulants use, corticosteroid use, hypertension, and atherosclerotic disease as factors significantly associated with diverticulosis. Alcohol related flushing was not associated with the disease. Multivariate analysis showed increasing age (P<0.01), increasing alcohol consumption (P<0.01) and smoking (P<0.01), and atherosclerotic disease (P<0.01) as significantly associated factors. Alcohol and smoking were associated with right-sided and bilateral diverticula. In conclusion, one in four Japanese adults have colonic diverticulosis (50% right-sided). Age, alcohol consumption, and smoking were found to be significant risk factors for uncomplicated colonic diverticulosis, particularly right-sided and bilateral.Naoyoshi NagataRyota NiikuraTakuro ShimboYoshihiro KishidaKatsunori SekineShohei TanakaTomonori AokiKazuhiro WatanabeJunichi AkiyamaMikio YanaseToshiyuki ItohMasashi MizokamiNaomi UemuraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e81137 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Naoyoshi Nagata Ryota Niikura Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Tomonori Aoki Kazuhiro Watanabe Junichi Akiyama Mikio Yanase Toshiyuki Itoh Masashi Mizokami Naomi Uemura Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan. |
| description |
Colonic diverticula are located predominantly on the right side in Asia and on the left side in Europe and the United States. Factors associated with uncomplicated colonic diverticulosis and its distribution pattern have been unknown. Our aims are to investigate the prevalence and risk factors for uncomplicated colonic diverticulosis. We conducted a prospective cross-sectional study in adults who underwent colonoscopy. Alcohol, alcohol related flushing, smoking, medications, and comorbidities were assessed by interview on the colonoscopy day. Alcohol consumption was categorized as nondrinker, light (1-180 g/week), moderate (181-360 g/week), and heavy (≥361 g/week). Smoking index was defined as the number of cigarettes per day multiplied by the number of smoking years and categorized as nonsmoker, <400, 400-799, and ≥800. A total of 2,164 consecutive patients were enrolled. Overall, 542 patients (25.1%) had uncomplicated colonic diverticulosis located on the right side (50%), bilaterally (29%), and on the left side (21%). Univariate analysis revealed age, male, smoking index, alcohol consumption, aspirin use, anticoagulants use, corticosteroid use, hypertension, and atherosclerotic disease as factors significantly associated with diverticulosis. Alcohol related flushing was not associated with the disease. Multivariate analysis showed increasing age (P<0.01), increasing alcohol consumption (P<0.01) and smoking (P<0.01), and atherosclerotic disease (P<0.01) as significantly associated factors. Alcohol and smoking were associated with right-sided and bilateral diverticula. In conclusion, one in four Japanese adults have colonic diverticulosis (50% right-sided). Age, alcohol consumption, and smoking were found to be significant risk factors for uncomplicated colonic diverticulosis, particularly right-sided and bilateral. |
| format |
article |
| author |
Naoyoshi Nagata Ryota Niikura Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Tomonori Aoki Kazuhiro Watanabe Junichi Akiyama Mikio Yanase Toshiyuki Itoh Masashi Mizokami Naomi Uemura |
| author_facet |
Naoyoshi Nagata Ryota Niikura Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Tomonori Aoki Kazuhiro Watanabe Junichi Akiyama Mikio Yanase Toshiyuki Itoh Masashi Mizokami Naomi Uemura |
| author_sort |
Naoyoshi Nagata |
| title |
Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan. |
| title_short |
Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan. |
| title_full |
Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan. |
| title_fullStr |
Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan. |
| title_full_unstemmed |
Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan. |
| title_sort |
alcohol and smoking affect risk of uncomplicated colonic diverticulosis in japan. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/90e2763f401d41208a2c8b856fc2b8fa |
| work_keys_str_mv |
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