CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis

Mehra et al. investigate the role of CdGAP in early biochemical recurrence and bone metastasis in prostate cancer. The authors find that knocking down CdGAP leads to reduced cell motility, invasion and proliferation in PC-3 and 22Rv1 cells while orthotopic injection of CdGAP-depleted PC-3 cells redu...

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Autores principales:	Chahat Mehra, Ji-Hyun Chung, Yi He, Mónica Lara-Márquez, Marie-Anne Goyette, Nadia Boufaied, Véronique Barrès, Véronique Ouellet, Karl-Phillippe Guérard, Carine Delliaux, Fred Saad, Jacques Lapointe, Jean-François Côté, David P. Labbé, Nathalie Lamarche-Vane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/90e48f7b139747d6ba6e98b737476318
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spelling	oai:doaj.org-article:90e48f7b139747d6ba6e98b7374763182021-12-02T14:58:44ZCdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis10.1038/s42003-021-02520-42399-3642https://doaj.org/article/90e48f7b139747d6ba6e98b7374763182021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02520-4https://doaj.org/toc/2399-3642Mehra et al. investigate the role of CdGAP in early biochemical recurrence and bone metastasis in prostate cancer. The authors find that knocking down CdGAP leads to reduced cell motility, invasion and proliferation in PC-3 and 22Rv1 cells while orthotopic injection of CdGAP-depleted PC-3 cells reduces distant metastatic burden.Chahat MehraJi-Hyun ChungYi HeMónica Lara-MárquezMarie-Anne GoyetteNadia BoufaiedVéronique BarrèsVéronique OuelletKarl-Phillippe GuérardCarine DelliauxFred SaadJacques LapointeJean-François CôtéDavid P. LabbéNathalie Lamarche-VaneNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Chahat Mehra Ji-Hyun Chung Yi He Mónica Lara-Márquez Marie-Anne Goyette Nadia Boufaied Véronique Barrès Véronique Ouellet Karl-Phillippe Guérard Carine Delliaux Fred Saad Jacques Lapointe Jean-François Côté David P. Labbé Nathalie Lamarche-Vane CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis
description	Mehra et al. investigate the role of CdGAP in early biochemical recurrence and bone metastasis in prostate cancer. The authors find that knocking down CdGAP leads to reduced cell motility, invasion and proliferation in PC-3 and 22Rv1 cells while orthotopic injection of CdGAP-depleted PC-3 cells reduces distant metastatic burden.
format	article
author	Chahat Mehra Ji-Hyun Chung Yi He Mónica Lara-Márquez Marie-Anne Goyette Nadia Boufaied Véronique Barrès Véronique Ouellet Karl-Phillippe Guérard Carine Delliaux Fred Saad Jacques Lapointe Jean-François Côté David P. Labbé Nathalie Lamarche-Vane
author_facet	Chahat Mehra Ji-Hyun Chung Yi He Mónica Lara-Márquez Marie-Anne Goyette Nadia Boufaied Véronique Barrès Véronique Ouellet Karl-Phillippe Guérard Carine Delliaux Fred Saad Jacques Lapointe Jean-François Côté David P. Labbé Nathalie Lamarche-Vane
author_sort	Chahat Mehra
title	CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis
title_short	CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis
title_full	CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis
title_fullStr	CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis
title_full_unstemmed	CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis
title_sort	cdgap promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90e48f7b139747d6ba6e98b737476318
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CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis

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