Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial

Abstract Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlle...

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Autores principales:	Jac Kee Low, Elizabeth Manias, Kimberley Crawford, Rowan Walker, William R. Mulley, Nigel D. Toussaint, Michael Dooley, Elaine Kennedy, Catherine L. Smith, Michelle Nalder, Doris Yip, Allison Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/90e58401413248de91f6cae200eee6c3
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spelling	oai:doaj.org-article:90e58401413248de91f6cae200eee6c32021-12-02T15:08:47ZImproving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial10.1038/s41598-019-44002-y2045-2322https://doaj.org/article/90e58401413248de91f6cae200eee6c32019-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44002-yhttps://doaj.org/toc/2045-2322Abstract Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlled trial was conducted at all five public hospitals providing adult kidney transplantation in Victoria, Australia. Participants were recruited at 4 to 6 weeks post-transplantation. Thirty-five participants were randomly assigned to a 3-month intervention, involving a face-to-face meeting (a medication review and a consumer-centred video) and health coaching every two weeks. Thirty-six were randomised to receive usual care. All participants were followed for nine months post-intervention. There were no differences in adherence between groups measured by Medication Event Monitoring System (MEMS), however, it was underutilised by 42% of participants. Based on the self-reported Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©) score, the percentage of adherent participants decreased significantly between baseline and 3 to 12 months in the control group (p-values < 0.001) whilst the percentage of adherent participants in the intervention group remained constant over time. No group differences were detected in other outcomes. Due to the complex medication regimen, developing and testing a medication adherence intervention is difficult in kidney transplantation.Jac Kee LowElizabeth ManiasKimberley CrawfordRowan WalkerWilliam R. MulleyNigel D. ToussaintMichael DooleyElaine KennedyCatherine L. SmithMichelle NalderDoris YipAllison WilliamsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jac Kee Low Elizabeth Manias Kimberley Crawford Rowan Walker William R. Mulley Nigel D. Toussaint Michael Dooley Elaine Kennedy Catherine L. Smith Michelle Nalder Doris Yip Allison Williams Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial
description	Abstract Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlled trial was conducted at all five public hospitals providing adult kidney transplantation in Victoria, Australia. Participants were recruited at 4 to 6 weeks post-transplantation. Thirty-five participants were randomly assigned to a 3-month intervention, involving a face-to-face meeting (a medication review and a consumer-centred video) and health coaching every two weeks. Thirty-six were randomised to receive usual care. All participants were followed for nine months post-intervention. There were no differences in adherence between groups measured by Medication Event Monitoring System (MEMS), however, it was underutilised by 42% of participants. Based on the self-reported Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©) score, the percentage of adherent participants decreased significantly between baseline and 3 to 12 months in the control group (p-values < 0.001) whilst the percentage of adherent participants in the intervention group remained constant over time. No group differences were detected in other outcomes. Due to the complex medication regimen, developing and testing a medication adherence intervention is difficult in kidney transplantation.
format	article
author	Jac Kee Low Elizabeth Manias Kimberley Crawford Rowan Walker William R. Mulley Nigel D. Toussaint Michael Dooley Elaine Kennedy Catherine L. Smith Michelle Nalder Doris Yip Allison Williams
author_facet	Jac Kee Low Elizabeth Manias Kimberley Crawford Rowan Walker William R. Mulley Nigel D. Toussaint Michael Dooley Elaine Kennedy Catherine L. Smith Michelle Nalder Doris Yip Allison Williams
author_sort	Jac Kee Low
title	Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial
title_short	Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial
title_full	Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial
title_fullStr	Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial
title_full_unstemmed	Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial
title_sort	improving medication adherence in adult kidney transplantation (imakt): a pilot randomised controlled trial
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/90e58401413248de91f6cae200eee6c3
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Improving medication adherence in adult kidney transplantation (IMAKT): A pilot randomised controlled trial

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