Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels

Forcing a DNA molecule into a nanoscale channel requires overcoming the free energy barrier associated with confinement. Here, the authors show that DNA injected through a funnel-shaped entrance more efficiently enters the nanochannel, thanks to facilitating forces generated by the nanofunnel geomet...

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Autores principales:	Jinsheng Zhou, Yanqian Wang, Laurent D. Menard, Sergey Panyukov, Michael Rubinstein, J. Michael Ramsey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90e75e0ea21644aba7c371d9aa9dd827
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id	oai:doaj.org-article:90e75e0ea21644aba7c371d9aa9dd827
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spelling	oai:doaj.org-article:90e75e0ea21644aba7c371d9aa9dd8272021-12-02T17:06:22ZEnhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels10.1038/s41467-017-00951-42041-1723https://doaj.org/article/90e75e0ea21644aba7c371d9aa9dd8272017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00951-4https://doaj.org/toc/2041-1723Forcing a DNA molecule into a nanoscale channel requires overcoming the free energy barrier associated with confinement. Here, the authors show that DNA injected through a funnel-shaped entrance more efficiently enters the nanochannel, thanks to facilitating forces generated by the nanofunnel geometry.Jinsheng ZhouYanqian WangLaurent D. MenardSergey PanyukovMichael RubinsteinJ. Michael RamseyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinsheng Zhou Yanqian Wang Laurent D. Menard Sergey Panyukov Michael Rubinstein J. Michael Ramsey Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels
description	Forcing a DNA molecule into a nanoscale channel requires overcoming the free energy barrier associated with confinement. Here, the authors show that DNA injected through a funnel-shaped entrance more efficiently enters the nanochannel, thanks to facilitating forces generated by the nanofunnel geometry.
format	article
author	Jinsheng Zhou Yanqian Wang Laurent D. Menard Sergey Panyukov Michael Rubinstein J. Michael Ramsey
author_facet	Jinsheng Zhou Yanqian Wang Laurent D. Menard Sergey Panyukov Michael Rubinstein J. Michael Ramsey
author_sort	Jinsheng Zhou
title	Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels
title_short	Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels
title_full	Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels
title_fullStr	Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels
title_full_unstemmed	Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels
title_sort	enhanced nanochannel translocation and localization of genomic dna molecules using three-dimensional nanofunnels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/90e75e0ea21644aba7c371d9aa9dd827
work_keys_str_mv	AT jinshengzhou enhancednanochanneltranslocationandlocalizationofgenomicdnamoleculesusingthreedimensionalnanofunnels AT yanqianwang enhancednanochanneltranslocationandlocalizationofgenomicdnamoleculesusingthreedimensionalnanofunnels AT laurentdmenard enhancednanochanneltranslocationandlocalizationofgenomicdnamoleculesusingthreedimensionalnanofunnels AT sergeypanyukov enhancednanochanneltranslocationandlocalizationofgenomicdnamoleculesusingthreedimensionalnanofunnels AT michaelrubinstein enhancednanochanneltranslocationandlocalizationofgenomicdnamoleculesusingthreedimensionalnanofunnels AT jmichaelramsey enhancednanochanneltranslocationandlocalizationofgenomicdnamoleculesusingthreedimensionalnanofunnels
_version_	1718381625054593024

Enhanced nanochannel translocation and localization of genomic DNA molecules using three-dimensional nanofunnels

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