PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secretion and fibrillogenesis of newly synthesized FN.
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Nature Portfolio
2016
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oai:doaj.org-article:90e8d111851f4825bda14ec5af3b94862021-12-02T15:33:47ZPPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis10.1038/ncomms135462041-1723https://doaj.org/article/90e8d111851f4825bda14ec5af3b94862016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13546https://doaj.org/toc/2041-1723During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secretion and fibrillogenesis of newly synthesized FN.Giulia ManaFabiana ClaperoEmiliano PanieriValentina PaneroRalph T. BöttcherHui-Yuan TsengFederico SaltarinElena AstaninaKatarzyna I. WolanskaMark R. MorganMartin J. HumphriesMassimo M. SantoroGuido SeriniDonatella ValdembriNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-20 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Giulia Mana Fabiana Clapero Emiliano Panieri Valentina Panero Ralph T. Böttcher Hui-Yuan Tseng Federico Saltarin Elena Astanina Katarzyna I. Wolanska Mark R. Morgan Martin J. Humphries Massimo M. Santoro Guido Serini Donatella Valdembri PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis |
| description |
During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secretion and fibrillogenesis of newly synthesized FN. |
| format |
article |
| author |
Giulia Mana Fabiana Clapero Emiliano Panieri Valentina Panero Ralph T. Böttcher Hui-Yuan Tseng Federico Saltarin Elena Astanina Katarzyna I. Wolanska Mark R. Morgan Martin J. Humphries Massimo M. Santoro Guido Serini Donatella Valdembri |
| author_facet |
Giulia Mana Fabiana Clapero Emiliano Panieri Valentina Panero Ralph T. Böttcher Hui-Yuan Tseng Federico Saltarin Elena Astanina Katarzyna I. Wolanska Mark R. Morgan Martin J. Humphries Massimo M. Santoro Guido Serini Donatella Valdembri |
| author_sort |
Giulia Mana |
| title |
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis |
| title_short |
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis |
| title_full |
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis |
| title_fullStr |
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis |
| title_full_unstemmed |
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis |
| title_sort |
ppfia1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/90e8d111851f4825bda14ec5af3b9486 |
| work_keys_str_mv |
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1718387038224384000 |