A miR-200b/200c/429-binding site polymorphism in the 3' untranslated region of the AP-2α gene is associated with cisplatin resistance.

The transcription factor AP-2α functions as a tumor suppressor by regulating various genes that are involved in cell proliferation and apoptosis. Chemotherapeutic drugs including cisplatin induce post-transcriptionally endogenous AP-2α, which contributes to chemosensitivity by enhancing therapy-indu...

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Autores principales: Yuan Wu, Yuzhong Xiao, Xiaofeng Ding, Yiming Zhuo, Peng Ren, Chang Zhou, Jianlin Zhou
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/90eaa4e59a864326abf666c5970a7e64
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