Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii

Ren et al. investigated how the obligate intracellular pathogen Toxoplasma gondii satisfies its requirement of phosphatidylinositol (PtdIns). They show that this parasite can synthesize certain PtdIns species de novo and salvages others from human host cells. Endogenous production of PtdIns in the G...

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Autores principales:	Bingjian Ren, Pengfei Kong, Fatima Hedar, Jos F. Brouwers, Nishith Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/90f0624e9da4496989d2f9b086c5acc8
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spelling	oai:doaj.org-article:90f0624e9da4496989d2f9b086c5acc82021-12-02T15:11:48ZPhosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii10.1038/s42003-020-01480-52399-3642https://doaj.org/article/90f0624e9da4496989d2f9b086c5acc82020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01480-5https://doaj.org/toc/2399-3642Ren et al. investigated how the obligate intracellular pathogen Toxoplasma gondii satisfies its requirement of phosphatidylinositol (PtdIns). They show that this parasite can synthesize certain PtdIns species de novo and salvages others from human host cells. Endogenous production of PtdIns in the Golgi complex is critical for the acute infection, and its loss perturbs homeostasis of selected anionic phospholipids.Bingjian RenPengfei KongFatima HedarJos F. BrouwersNishith GuptaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bingjian Ren Pengfei Kong Fatima Hedar Jos F. Brouwers Nishith Gupta Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii
description	Ren et al. investigated how the obligate intracellular pathogen Toxoplasma gondii satisfies its requirement of phosphatidylinositol (PtdIns). They show that this parasite can synthesize certain PtdIns species de novo and salvages others from human host cells. Endogenous production of PtdIns in the Golgi complex is critical for the acute infection, and its loss perturbs homeostasis of selected anionic phospholipids.
format	article
author	Bingjian Ren Pengfei Kong Fatima Hedar Jos F. Brouwers Nishith Gupta
author_facet	Bingjian Ren Pengfei Kong Fatima Hedar Jos F. Brouwers Nishith Gupta
author_sort	Bingjian Ren
title	Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii
title_short	Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii
title_full	Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii
title_fullStr	Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii
title_full_unstemmed	Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii
title_sort	phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in toxoplasma gondii
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/90f0624e9da4496989d2f9b086c5acc8
work_keys_str_mv	AT bingjianren phosphatidylinositolsynthesisitsselectivesalvageandinterregulationofanionicphospholipidsintoxoplasmagondii AT pengfeikong phosphatidylinositolsynthesisitsselectivesalvageandinterregulationofanionicphospholipidsintoxoplasmagondii AT fatimahedar phosphatidylinositolsynthesisitsselectivesalvageandinterregulationofanionicphospholipidsintoxoplasmagondii AT josfbrouwers phosphatidylinositolsynthesisitsselectivesalvageandinterregulationofanionicphospholipidsintoxoplasmagondii AT nishithgupta phosphatidylinositolsynthesisitsselectivesalvageandinterregulationofanionicphospholipidsintoxoplasmagondii
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Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii

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