Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The evolution of immune landscape in lung adenocarcinoma (ADC) is largely unknown. Here the authors use a cohort of resected invasive lung ADC and its precursors and show a gradual increase of immunosuppression and decrease of anti-tumor response associated with specific genomic and epigenetic featu...

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Autores principales:	Hitoshi Dejima, Xin Hu, Runzhe Chen, Jiexin Zhang, Junya Fujimoto, Edwin R. Parra, Cara Haymaker, Shawna M. Hubert, Dzifa Duose, Luisa M. Solis, Dan Su, Junya Fukuoka, Kazuhiro Tabata, Hoa H. N. Pham, Nicholas Mcgranahan, Baili Zhang, Jie Ye, Lisha Ying, Latasha Little, Curtis Gumbs, Chi-Wan Chow, Marcos Roberto Estecio, Myrna C. B. Godoy, Mara B. Antonoff, Boris Sepesi, Harvey I. Pass, Carmen Behrens, Jianhua Zhang, Ara A. Vaporciyan, John V. Heymach, Paul Scheet, J. Jack Lee, Jia Wu, P. Andrew Futreal, Alexandre Reuben, Humam Kadara, Ignacio I. Wistuba, Jianjun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90f6cd0b92e742178a0fc4cce008b8e0
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spelling	oai:doaj.org-article:90f6cd0b92e742178a0fc4cce008b8e02021-12-02T16:58:19ZImmune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features10.1038/s41467-021-22890-x2041-1723https://doaj.org/article/90f6cd0b92e742178a0fc4cce008b8e02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22890-xhttps://doaj.org/toc/2041-1723The evolution of immune landscape in lung adenocarcinoma (ADC) is largely unknown. Here the authors use a cohort of resected invasive lung ADC and its precursors and show a gradual increase of immunosuppression and decrease of anti-tumor response associated with specific genomic and epigenetic features.Hitoshi DejimaXin HuRunzhe ChenJiexin ZhangJunya FujimotoEdwin R. ParraCara HaymakerShawna M. HubertDzifa DuoseLuisa M. SolisDan SuJunya FukuokaKazuhiro TabataHoa H. N. PhamNicholas McgranahanBaili ZhangJie YeLisha YingLatasha LittleCurtis GumbsChi-Wan ChowMarcos Roberto EstecioMyrna C. B. GodoyMara B. AntonoffBoris SepesiHarvey I. PassCarmen BehrensJianhua ZhangAra A. VaporciyanJohn V. HeymachPaul ScheetJ. Jack LeeJia WuP. Andrew FutrealAlexandre ReubenHumam KadaraIgnacio I. WistubaJianjun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hitoshi Dejima Xin Hu Runzhe Chen Jiexin Zhang Junya Fujimoto Edwin R. Parra Cara Haymaker Shawna M. Hubert Dzifa Duose Luisa M. Solis Dan Su Junya Fukuoka Kazuhiro Tabata Hoa H. N. Pham Nicholas Mcgranahan Baili Zhang Jie Ye Lisha Ying Latasha Little Curtis Gumbs Chi-Wan Chow Marcos Roberto Estecio Myrna C. B. Godoy Mara B. Antonoff Boris Sepesi Harvey I. Pass Carmen Behrens Jianhua Zhang Ara A. Vaporciyan John V. Heymach Paul Scheet J. Jack Lee Jia Wu P. Andrew Futreal Alexandre Reuben Humam Kadara Ignacio I. Wistuba Jianjun Zhang Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
description	The evolution of immune landscape in lung adenocarcinoma (ADC) is largely unknown. Here the authors use a cohort of resected invasive lung ADC and its precursors and show a gradual increase of immunosuppression and decrease of anti-tumor response associated with specific genomic and epigenetic features.
format	article
author	Hitoshi Dejima Xin Hu Runzhe Chen Jiexin Zhang Junya Fujimoto Edwin R. Parra Cara Haymaker Shawna M. Hubert Dzifa Duose Luisa M. Solis Dan Su Junya Fukuoka Kazuhiro Tabata Hoa H. N. Pham Nicholas Mcgranahan Baili Zhang Jie Ye Lisha Ying Latasha Little Curtis Gumbs Chi-Wan Chow Marcos Roberto Estecio Myrna C. B. Godoy Mara B. Antonoff Boris Sepesi Harvey I. Pass Carmen Behrens Jianhua Zhang Ara A. Vaporciyan John V. Heymach Paul Scheet J. Jack Lee Jia Wu P. Andrew Futreal Alexandre Reuben Humam Kadara Ignacio I. Wistuba Jianjun Zhang
author_facet	Hitoshi Dejima Xin Hu Runzhe Chen Jiexin Zhang Junya Fujimoto Edwin R. Parra Cara Haymaker Shawna M. Hubert Dzifa Duose Luisa M. Solis Dan Su Junya Fukuoka Kazuhiro Tabata Hoa H. N. Pham Nicholas Mcgranahan Baili Zhang Jie Ye Lisha Ying Latasha Little Curtis Gumbs Chi-Wan Chow Marcos Roberto Estecio Myrna C. B. Godoy Mara B. Antonoff Boris Sepesi Harvey I. Pass Carmen Behrens Jianhua Zhang Ara A. Vaporciyan John V. Heymach Paul Scheet J. Jack Lee Jia Wu P. Andrew Futreal Alexandre Reuben Humam Kadara Ignacio I. Wistuba Jianjun Zhang
author_sort	Hitoshi Dejima
title	Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
title_short	Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
title_full	Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
title_fullStr	Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
title_full_unstemmed	Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
title_sort	immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/90f6cd0b92e742178a0fc4cce008b8e0
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Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

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