A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings

Introduction: Lupus nephritis is one of the important aspects of systemic lupus erythematosus (SLE). Objectives: This study aimed to investigate possible relationship between pathological lesions of lupus nephritis classes and demographic and biochemical findings among patients. Patients and Methods...

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Autores principales:	Nasrin Tavassoli, Hamid Nasri, Rohollah Valizadeh
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2022
Materias:	lupus nephritis systemic lupus erythematosus proteinuria Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/90fe78d66bb14999bc63f5c190bc640b
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spelling	oai:doaj.org-article:90fe78d66bb14999bc63f5c190bc640b2021-11-16T10:42:13ZA study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings2476-393410.34172/jpe.2022.10https://doaj.org/article/90fe78d66bb14999bc63f5c190bc640b2022-01-01T00:00:00Zhttps://jprevepi.com/PDF/jpe-7-e10.pdfhttps://doaj.org/toc/2476-3934Introduction: Lupus nephritis is one of the important aspects of systemic lupus erythematosus (SLE). Objectives: This study aimed to investigate possible relationship between pathological lesions of lupus nephritis classes and demographic and biochemical findings among patients. Patients and Methods: This is a cross-sectional study that was conducted on a group of renal biopsy proven lupus nephritis patients using lupus nephritis classification of ISN/RPS 2003. We collected demographic data of all patients including age, gender serum creatinine and 24h proteinuria. Results: Data of 101 patients, of whom 78 (77.23%) were females and mean age of 33.54±13.15 years. The mean serum creatinine and proteinuria were 1.54±0.88 mg/dL 2502.5±1495.05 mg/d. Based on our data, IV-G (class IV, diffuse lupus nephritis-global) lupus nephritis class was the most common (39.6%) followed by class III (23.8%). The mean crescent and sclerotic glomeruli were 1.66±3.32 and 2.27±5.32, respectively. In this study, 24 hours proteinuria, serum creatinine, activity percent, chronicity percent, crescent and glomerular sclerosis between genders showed no significant differences (P>0.05). The correlation between plasma creatinine and activity was directly positive and significant (r=0.381, P=0.001). In addition, a significant correlation between C1q deposits and glomerular sclerosis (P=0.031) was detected. Accordingly, a significant correlation between IgG deposits and lupus nephritis classification (P=0.025) was seen. Conclusion: Lupus nephritis of IV-G and III classes of lupus nephritis were most common among patients and higher IgG deposits were observed in patients with IV-G classification. We found a significant correlation between glomerular sclerosis and C1q deposits that could be an indicator of lupus nephritis activity and severity. However, we recommend further studies in this regard.Nasrin TavassoliHamid NasriRohollah ValizadehSociety of Diabetic Nephropathy Preventionarticlelupus nephritissystemic lupus erythematosusproteinuriaSpecialties of internal medicineRC581-951Infectious and parasitic diseasesRC109-216ENJournal of Preventive Epidemiology, Vol 7, Iss 1, Pp e10-e10 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	lupus nephritis systemic lupus erythematosus proteinuria Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216
spellingShingle	lupus nephritis systemic lupus erythematosus proteinuria Specialties of internal medicine RC581-951 Infectious and parasitic diseases RC109-216 Nasrin Tavassoli Hamid Nasri Rohollah Valizadeh A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings
description	Introduction: Lupus nephritis is one of the important aspects of systemic lupus erythematosus (SLE). Objectives: This study aimed to investigate possible relationship between pathological lesions of lupus nephritis classes and demographic and biochemical findings among patients. Patients and Methods: This is a cross-sectional study that was conducted on a group of renal biopsy proven lupus nephritis patients using lupus nephritis classification of ISN/RPS 2003. We collected demographic data of all patients including age, gender serum creatinine and 24h proteinuria. Results: Data of 101 patients, of whom 78 (77.23%) were females and mean age of 33.54±13.15 years. The mean serum creatinine and proteinuria were 1.54±0.88 mg/dL 2502.5±1495.05 mg/d. Based on our data, IV-G (class IV, diffuse lupus nephritis-global) lupus nephritis class was the most common (39.6%) followed by class III (23.8%). The mean crescent and sclerotic glomeruli were 1.66±3.32 and 2.27±5.32, respectively. In this study, 24 hours proteinuria, serum creatinine, activity percent, chronicity percent, crescent and glomerular sclerosis between genders showed no significant differences (P>0.05). The correlation between plasma creatinine and activity was directly positive and significant (r=0.381, P=0.001). In addition, a significant correlation between C1q deposits and glomerular sclerosis (P=0.031) was detected. Accordingly, a significant correlation between IgG deposits and lupus nephritis classification (P=0.025) was seen. Conclusion: Lupus nephritis of IV-G and III classes of lupus nephritis were most common among patients and higher IgG deposits were observed in patients with IV-G classification. We found a significant correlation between glomerular sclerosis and C1q deposits that could be an indicator of lupus nephritis activity and severity. However, we recommend further studies in this regard.
format	article
author	Nasrin Tavassoli Hamid Nasri Rohollah Valizadeh
author_facet	Nasrin Tavassoli Hamid Nasri Rohollah Valizadeh
author_sort	Nasrin Tavassoli
title	A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings
title_short	A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings
title_full	A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings
title_fullStr	A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings
title_full_unstemmed	A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings
title_sort	study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2022
url	https://doaj.org/article/90fe78d66bb14999bc63f5c190bc640b
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A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings

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