Avian and human influenza virus compatible sialic acid receptors in little brown bats

Abstract Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questio...

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Autores principales:	Shubhada K. Chothe, Gitanjali Bhushan, Ruth H. Nissly, Yin-Ting Yeh, Justin Brown, Gregory Turner, Jenny Fisher, Brent J. Sewall, DeeAnn M. Reeder, Mauricio Terrones, Bhushan M. Jayarao, Suresh V. Kuchipudi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/91022435b2294b479515034568872ab4
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spelling	oai:doaj.org-article:91022435b2294b479515034568872ab42021-12-02T16:07:49ZAvian and human influenza virus compatible sialic acid receptors in little brown bats10.1038/s41598-017-00793-62045-2322https://doaj.org/article/91022435b2294b479515034568872ab42017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00793-6https://doaj.org/toc/2045-2322Abstract Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.Shubhada K. ChotheGitanjali BhushanRuth H. NisslyYin-Ting YehJustin BrownGregory TurnerJenny FisherBrent J. SewallDeeAnn M. ReederMauricio TerronesBhushan M. JayaraoSuresh V. KuchipudiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shubhada K. Chothe Gitanjali Bhushan Ruth H. Nissly Yin-Ting Yeh Justin Brown Gregory Turner Jenny Fisher Brent J. Sewall DeeAnn M. Reeder Mauricio Terrones Bhushan M. Jayarao Suresh V. Kuchipudi Avian and human influenza virus compatible sialic acid receptors in little brown bats
description	Abstract Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.
format	article
author	Shubhada K. Chothe Gitanjali Bhushan Ruth H. Nissly Yin-Ting Yeh Justin Brown Gregory Turner Jenny Fisher Brent J. Sewall DeeAnn M. Reeder Mauricio Terrones Bhushan M. Jayarao Suresh V. Kuchipudi
author_facet	Shubhada K. Chothe Gitanjali Bhushan Ruth H. Nissly Yin-Ting Yeh Justin Brown Gregory Turner Jenny Fisher Brent J. Sewall DeeAnn M. Reeder Mauricio Terrones Bhushan M. Jayarao Suresh V. Kuchipudi
author_sort	Shubhada K. Chothe
title	Avian and human influenza virus compatible sialic acid receptors in little brown bats
title_short	Avian and human influenza virus compatible sialic acid receptors in little brown bats
title_full	Avian and human influenza virus compatible sialic acid receptors in little brown bats
title_fullStr	Avian and human influenza virus compatible sialic acid receptors in little brown bats
title_full_unstemmed	Avian and human influenza virus compatible sialic acid receptors in little brown bats
title_sort	avian and human influenza virus compatible sialic acid receptors in little brown bats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/91022435b2294b479515034568872ab4
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Avian and human influenza virus compatible sialic acid receptors in little brown bats

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