Functional connectivity of paired default mode network subregions in primary insomnia

Xiao Nie,1,* Yi Shao,2,* Si-yu Liu,3 Hai-jun Li,1 Ai-lan Wan,4 Si Nie,1 De-chang Peng,1 Xi-jian Dai1,5 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Ophthalmology,The First Affiliated Hospital...

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Autores principales:	Nie X, Shao Y, Liu SY, Li HJ, Wan AL, Nie S, Peng DC, Dai XJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Primary insomnia Functional connectivity Default mode network Functional magnetic resonance imaging Functional magnetic ressonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9102bb0dfcca4ff5874d03a0acc65fc7
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spelling	oai:doaj.org-article:9102bb0dfcca4ff5874d03a0acc65fc72021-12-02T05:41:04ZFunctional connectivity of paired default mode network subregions in primary insomnia1178-2021https://doaj.org/article/9102bb0dfcca4ff5874d03a0acc65fc72015-12-01T00:00:00Zhttps://www.dovepress.com/functional-connectivity-of-paired-default-mode-network-subregions-in-p-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiao Nie,1,* Yi Shao,2,* Si-yu Liu,3 Hai-jun Li,1 Ai-lan Wan,4 Si Nie,1 De-chang Peng,1 Xi-jian Dai1,5 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Ophthalmology,The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 3Medical College of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 4Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 5Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study is to explore the resting-state functional connectivity (FC) differences between the paired default mode network (DMN) subregions in patients with primary insomnia (PIs).Methods: Forty-two PIs and forty-two age- and sex-matched good sleepers (GSs) were recruited. All subjects underwent the resting-state functional magnetic resonance imaging scans. The seed-based region-to-region FC method was used to evaluate the abnormal connectivity within the DMN subregions between the PIs and the GSs. Pearson correlation analysis was used to investigate the relationships between the abnormal FC strength within the paired DMN subregions and the clinical features in PIs.Results: Compared with the GSs, the PIs showed higher Pittsburgh Sleep Quality Index score, Hamilton Anxiety Rating Scale score, Hamilton Depression Rating Scale score, Self-Rating Depression Scale score, Self Rating Anxiety Scale score, Self-Rating Scale of Sleep score, and Profile of Mood States score (P<0.001). Compared with the GSs, the PIs showed significant decreased region-to-region FC between the medial prefrontal cortex and the right medial temporal lobe (t=-2.275, P=0.026), and between the left medial temporal lobe and the left inferior parietal cortices (t=-3.32, P=0.001). The abnormal FC strengths between the DMN subregions did not correlate with the clinical features.Conclusion: PIs showed disrupted FC within the DMN subregions. Keywords: insomnia, functional connectivity, default mode network, functional magnetic resonance imaging, resting-state, blood oxygenation level dependentNie XShao YLiu SYLi HJWan ALNie SPeng DCDai XJDove Medical PressarticlePrimary insomniaFunctional connectivityDefault mode networkFunctional magnetic resonance imagingFunctional magnetic ressonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss Issue 1, Pp 3085-3093 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Primary insomnia Functional connectivity Default mode network Functional magnetic resonance imaging Functional magnetic ressonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Primary insomnia Functional connectivity Default mode network Functional magnetic resonance imaging Functional magnetic ressonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Nie X Shao Y Liu SY Li HJ Wan AL Nie S Peng DC Dai XJ Functional connectivity of paired default mode network subregions in primary insomnia
description	Xiao Nie,1,* Yi Shao,2,* Si-yu Liu,3 Hai-jun Li,1 Ai-lan Wan,4 Si Nie,1 De-chang Peng,1 Xi-jian Dai1,5 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Ophthalmology,The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 3Medical College of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 4Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 5Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study is to explore the resting-state functional connectivity (FC) differences between the paired default mode network (DMN) subregions in patients with primary insomnia (PIs).Methods: Forty-two PIs and forty-two age- and sex-matched good sleepers (GSs) were recruited. All subjects underwent the resting-state functional magnetic resonance imaging scans. The seed-based region-to-region FC method was used to evaluate the abnormal connectivity within the DMN subregions between the PIs and the GSs. Pearson correlation analysis was used to investigate the relationships between the abnormal FC strength within the paired DMN subregions and the clinical features in PIs.Results: Compared with the GSs, the PIs showed higher Pittsburgh Sleep Quality Index score, Hamilton Anxiety Rating Scale score, Hamilton Depression Rating Scale score, Self-Rating Depression Scale score, Self Rating Anxiety Scale score, Self-Rating Scale of Sleep score, and Profile of Mood States score (P<0.001). Compared with the GSs, the PIs showed significant decreased region-to-region FC between the medial prefrontal cortex and the right medial temporal lobe (t=-2.275, P=0.026), and between the left medial temporal lobe and the left inferior parietal cortices (t=-3.32, P=0.001). The abnormal FC strengths between the DMN subregions did not correlate with the clinical features.Conclusion: PIs showed disrupted FC within the DMN subregions. Keywords: insomnia, functional connectivity, default mode network, functional magnetic resonance imaging, resting-state, blood oxygenation level dependent
format	article
author	Nie X Shao Y Liu SY Li HJ Wan AL Nie S Peng DC Dai XJ
author_facet	Nie X Shao Y Liu SY Li HJ Wan AL Nie S Peng DC Dai XJ
author_sort	Nie X
title	Functional connectivity of paired default mode network subregions in primary insomnia
title_short	Functional connectivity of paired default mode network subregions in primary insomnia
title_full	Functional connectivity of paired default mode network subregions in primary insomnia
title_fullStr	Functional connectivity of paired default mode network subregions in primary insomnia
title_full_unstemmed	Functional connectivity of paired default mode network subregions in primary insomnia
title_sort	functional connectivity of paired default mode network subregions in primary insomnia
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/9102bb0dfcca4ff5874d03a0acc65fc7
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_version_	1718400244585070592

Functional connectivity of paired default mode network subregions in primary insomnia

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