A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis.

A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis.

<h4>Background aims</h4>Primary sclerosing cholangitis predominantly affects males and is an important indication for liver transplantation. The rs738409 variant (I148M) of the PNPLA3 gene is associated with alcoholic and non-alcoholic liver disease and we evaluated its impact on the dis...

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Autores principales: Kilian Friedrich, Christian Rupp, Johannes Roksund Hov, Niels Steinebrunner, Karl-Heinz Weiss, Adolf Stiehl, Maik Brune, Petra Kloeters Yvonne Schaefer, Peter Schemmer, Peter Sauer, Peter Schirmacher, Heiko Runz, Tom Hemming Karlsen, Wolfgang Stremmel, Daniel Nils Gotthardt
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9102ced40ef94cce837eefe5c840c95d
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