Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type

BACKGROUND AND OBJECTIVE: Colorectal cancer is one of the growing cancers in Iran and one of the few preventable cancers in the World Health Organization. One of the most important ways to early diagnose this malignancy and its underlying lesions (polyps) and subsequently to prevent it is screening....

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Autores principales:	SH Abedi Valukalaie, MR Dini, H Asadzadeh Aghdaei, MR Zali
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	colorectal cancer colorectal cancer familial lynch syndrome colorectal cancer x-type. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9106f8d525f84f828e8678a63f33d5c6
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spelling	oai:doaj.org-article:9106f8d525f84f828e8678a63f33d5c62021-11-09T10:15:54ZEvaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type1561-41072251-7170https://doaj.org/article/9106f8d525f84f828e8678a63f33d5c62020-03-01T00:00:00Zhttp://jbums.org/article-1-8552-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Colorectal cancer is one of the growing cancers in Iran and one of the few preventable cancers in the World Health Organization. One of the most important ways to early diagnose this malignancy and its underlying lesions (polyps) and subsequently to prevent it is screening. Colorectal cancer is one of the growing cancers in Iran and one of the few preventable cancers in the World Health Organization. One of the most important ways of early detection of this malignancy and its underlying lesions (polyps) and consequently its prevention is screening. Different protocols have been developed for the diagnosis of first degree relatives of known hereditary cases such as HNPCC and FAP, but the diagnosis plan for first degree relatives has not been defined as a group of familial colorectal cancers without known mutations (type X colorectal cancer). The purpose of this study was to evaluate the results of colonoscopy screening in first-degree relatives of these patients. METHODS: This cross-sectional study was performed on the families of patients with suspected Lynch syndrome who had no deficiency in the expression of repair proteins. Data were collected from the medical records system of colorectal cancer patients who had been enrolled in the system for prevention and early detection of colorectal cancer at Shahid Beheshti University of Medical Sciences Research Center from 1387 to 1397. FINDINGS: The results of colonoscopy revealed that 18 out of 77 subjects had 23% polyps or tumors in their colon, out of which 55% were polyps and the rest were adenomas. About 60% of polyps were in the rectum and sigmoid and the rest in the colon and cecum. Also, 4 patients in this screening showed tumors in their colon, all of which were newly diagnosed, and 2 patients in this screening were diagnosed with inflammatory bowel disease. CONCLUSION: According to the results of this study, in the case of colon polyps, the families of these patients appear to be at high risk like those of Lynch syndrome families and need regular colonoscopy care.SH Abedi ValukalaieMR DiniH Asadzadeh AghdaeiMR ZaliBabol University of Medical Sciencesarticlecolorectal cancercolorectal cancer familiallynch syndromecolorectal cancer x-type.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 53-58 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	colorectal cancer colorectal cancer familial lynch syndrome colorectal cancer x-type. Medicine R Medicine (General) R5-920
spellingShingle	colorectal cancer colorectal cancer familial lynch syndrome colorectal cancer x-type. Medicine R Medicine (General) R5-920 SH Abedi Valukalaie MR Dini H Asadzadeh Aghdaei MR Zali Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type
description	BACKGROUND AND OBJECTIVE: Colorectal cancer is one of the growing cancers in Iran and one of the few preventable cancers in the World Health Organization. One of the most important ways to early diagnose this malignancy and its underlying lesions (polyps) and subsequently to prevent it is screening. Colorectal cancer is one of the growing cancers in Iran and one of the few preventable cancers in the World Health Organization. One of the most important ways of early detection of this malignancy and its underlying lesions (polyps) and consequently its prevention is screening. Different protocols have been developed for the diagnosis of first degree relatives of known hereditary cases such as HNPCC and FAP, but the diagnosis plan for first degree relatives has not been defined as a group of familial colorectal cancers without known mutations (type X colorectal cancer). The purpose of this study was to evaluate the results of colonoscopy screening in first-degree relatives of these patients. METHODS: This cross-sectional study was performed on the families of patients with suspected Lynch syndrome who had no deficiency in the expression of repair proteins. Data were collected from the medical records system of colorectal cancer patients who had been enrolled in the system for prevention and early detection of colorectal cancer at Shahid Beheshti University of Medical Sciences Research Center from 1387 to 1397. FINDINGS: The results of colonoscopy revealed that 18 out of 77 subjects had 23% polyps or tumors in their colon, out of which 55% were polyps and the rest were adenomas. About 60% of polyps were in the rectum and sigmoid and the rest in the colon and cecum. Also, 4 patients in this screening showed tumors in their colon, all of which were newly diagnosed, and 2 patients in this screening were diagnosed with inflammatory bowel disease. CONCLUSION: According to the results of this study, in the case of colon polyps, the families of these patients appear to be at high risk like those of Lynch syndrome families and need regular colonoscopy care.
format	article
author	SH Abedi Valukalaie MR Dini H Asadzadeh Aghdaei MR Zali
author_facet	SH Abedi Valukalaie MR Dini H Asadzadeh Aghdaei MR Zali
author_sort	SH Abedi Valukalaie
title	Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type
title_short	Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type
title_full	Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type
title_fullStr	Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type
title_full_unstemmed	Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type
title_sort	evaluation of colonoscopy screening results in the first-degree relatives of patients with familial colorectal cancer x-type
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/9106f8d525f84f828e8678a63f33d5c6
work_keys_str_mv	AT shabedivalukalaie evaluationofcolonoscopyscreeningresultsinthefirstdegreerelativesofpatientswithfamilialcolorectalcancerxtype AT mrdini evaluationofcolonoscopyscreeningresultsinthefirstdegreerelativesofpatientswithfamilialcolorectalcancerxtype AT hasadzadehaghdaei evaluationofcolonoscopyscreeningresultsinthefirstdegreerelativesofpatientswithfamilialcolorectalcancerxtype AT mrzali evaluationofcolonoscopyscreeningresultsinthefirstdegreerelativesofpatientswithfamilialcolorectalcancerxtype
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Evaluation of Colonoscopy Screening Results in the First-Degree Relatives of Patients with Familial Colorectal Cancer X-Type

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