Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

The APOE4 allele is the leading risk factor for late-onset Alzheimer’s disease, but how it might contribute to the disease is not clear. Here the authors show that a mouse expressing the human APOE4 allele displays hyperactivity in the entorhinal cortex due to a decreased inhibitory tone, which may...

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Autores principales:	Tal Nuriel, Sergio L. Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y. Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S. Gross, S. Abid Hussaini, Herman Moreno, Scott A. Small, Karen E. Duff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91098ce8e7d943429a161e6bc0ddcf3e
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spelling	oai:doaj.org-article:91098ce8e7d943429a161e6bc0ddcf3e2021-12-02T17:01:18ZNeuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology10.1038/s41467-017-01444-02041-1723https://doaj.org/article/91098ce8e7d943429a161e6bc0ddcf3e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01444-0https://doaj.org/toc/2041-1723The APOE4 allele is the leading risk factor for late-onset Alzheimer’s disease, but how it might contribute to the disease is not clear. Here the authors show that a mouse expressing the human APOE4 allele displays hyperactivity in the entorhinal cortex due to a decreased inhibitory tone, which may in part explain accelerated Alzheimer’s pathology in APOE4 carriers.Tal NurielSergio L. AnguloUsman KhanArchana AshokQiuying ChenHelen Y. FigueroaSheina EmraniLi LiuMathieu HermanGeoffrey BarrettValerie SavageLuna BuitragoEfrain Cepeda-PradoChristine FungEliana GoldbergSteven S. GrossS. Abid HussainiHerman MorenoScott A. SmallKaren E. DuffNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tal Nuriel Sergio L. Angulo Usman Khan Archana Ashok Qiuying Chen Helen Y. Figueroa Sheina Emrani Li Liu Mathieu Herman Geoffrey Barrett Valerie Savage Luna Buitrago Efrain Cepeda-Prado Christine Fung Eliana Goldberg Steven S. Gross S. Abid Hussaini Herman Moreno Scott A. Small Karen E. Duff Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
description	The APOE4 allele is the leading risk factor for late-onset Alzheimer’s disease, but how it might contribute to the disease is not clear. Here the authors show that a mouse expressing the human APOE4 allele displays hyperactivity in the entorhinal cortex due to a decreased inhibitory tone, which may in part explain accelerated Alzheimer’s pathology in APOE4 carriers.
format	article
author	Tal Nuriel Sergio L. Angulo Usman Khan Archana Ashok Qiuying Chen Helen Y. Figueroa Sheina Emrani Li Liu Mathieu Herman Geoffrey Barrett Valerie Savage Luna Buitrago Efrain Cepeda-Prado Christine Fung Eliana Goldberg Steven S. Gross S. Abid Hussaini Herman Moreno Scott A. Small Karen E. Duff
author_facet	Tal Nuriel Sergio L. Angulo Usman Khan Archana Ashok Qiuying Chen Helen Y. Figueroa Sheina Emrani Li Liu Mathieu Herman Geoffrey Barrett Valerie Savage Luna Buitrago Efrain Cepeda-Prado Christine Fung Eliana Goldberg Steven S. Gross S. Abid Hussaini Herman Moreno Scott A. Small Karen E. Duff
author_sort	Tal Nuriel
title	Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
title_short	Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
title_full	Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
title_fullStr	Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
title_full_unstemmed	Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
title_sort	neuronal hyperactivity due to loss of inhibitory tone in apoe4 mice lacking alzheimer’s disease-like pathology
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/91098ce8e7d943429a161e6bc0ddcf3e
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Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

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