CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages

IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus facilitating an inflammatory response

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Autores principales:	Milton Pereira, Panagiotis Tourlomousis, John Wright, Tom P. Monie, Clare E. Bryant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91099d9564cf4df599100a407c0ed7a7
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spelling	oai:doaj.org-article:91099d9564cf4df599100a407c0ed7a72021-12-02T17:32:51ZCARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages10.1038/ncomms128742041-1723https://doaj.org/article/91099d9564cf4df599100a407c0ed7a72016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12874https://doaj.org/toc/2041-1723IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus facilitating an inflammatory responseMilton PereiraPanagiotis TourlomousisJohn WrightTom P. MonieClare E. BryantNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Milton Pereira Panagiotis Tourlomousis John Wright Tom P. Monie Clare E. Bryant CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
description	IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus facilitating an inflammatory response
format	article
author	Milton Pereira Panagiotis Tourlomousis John Wright Tom P. Monie Clare E. Bryant
author_facet	Milton Pereira Panagiotis Tourlomousis John Wright Tom P. Monie Clare E. Bryant
author_sort	Milton Pereira
title	CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
title_short	CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
title_full	CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
title_fullStr	CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
title_full_unstemmed	CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
title_sort	card9 negatively regulates nlrp3-induced il-1β production on salmonella infection of macrophages
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/91099d9564cf4df599100a407c0ed7a7
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CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages

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