Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids

Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids

Cell proliferation is regulated by cell volume, but it is unclear how individual cancer cells coordinate to regulate cell volumes in 3D clusters. Here the authors propose a mechano-osmotic model to analyse the exchange of fluid and ions between connected cells and their environment in response to pr...

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Autores principales: Eoin McEvoy, Yu Long Han, Ming Guo, Vivek B. Shenoy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/910b424081314b0c8a8c38637980ddf6
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spelling oai:doaj.org-article:910b424081314b0c8a8c38637980ddf62021-12-02T17:32:14ZGap junctions amplify spatial variations in cell volume in proliferating tumor spheroids10.1038/s41467-020-19904-52041-1723https://doaj.org/article/910b424081314b0c8a8c38637980ddf62020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19904-5https://doaj.org/toc/2041-1723Cell proliferation is regulated by cell volume, but it is unclear how individual cancer cells coordinate to regulate cell volumes in 3D clusters. Here the authors propose a mechano-osmotic model to analyse the exchange of fluid and ions between connected cells and their environment in response to proliferation-induced solid stress.Eoin McEvoyYu Long HanMing GuoVivek B. ShenoyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Eoin McEvoy
Yu Long Han
Ming Guo
Vivek B. Shenoy
Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
description Cell proliferation is regulated by cell volume, but it is unclear how individual cancer cells coordinate to regulate cell volumes in 3D clusters. Here the authors propose a mechano-osmotic model to analyse the exchange of fluid and ions between connected cells and their environment in response to proliferation-induced solid stress.
format article
author Eoin McEvoy
Yu Long Han
Ming Guo
Vivek B. Shenoy
author_facet Eoin McEvoy
Yu Long Han
Ming Guo
Vivek B. Shenoy
author_sort Eoin McEvoy
title Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
title_short Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
title_full Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
title_fullStr Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
title_full_unstemmed Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
title_sort gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/910b424081314b0c8a8c38637980ddf6
work_keys_str_mv AT eoinmcevoy gapjunctionsamplifyspatialvariationsincellvolumeinproliferatingtumorspheroids
AT yulonghan gapjunctionsamplifyspatialvariationsincellvolumeinproliferatingtumorspheroids
AT mingguo gapjunctionsamplifyspatialvariationsincellvolumeinproliferatingtumorspheroids
AT vivekbshenoy gapjunctionsamplifyspatialvariationsincellvolumeinproliferatingtumorspheroids
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