Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Enhancement of haematopoietic stem cell (HSC) homing and engraftment is critical for haematopoietic cell transplantation. Here, the authors find that HDAC5 inhibition enhances HSC homing and engraftment by increasing p65 acetylation and enhancing NF-kB mediated CXCR4 transcription.

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Autores principales:	Xinxin Huang, Bin Guo, Sheng Liu, Jun Wan, Hal E. Broxmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/910fcb79df52422ca7960ee3a2ab082f
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spelling	oai:doaj.org-article:910fcb79df52422ca7960ee3a2ab082f2021-12-02T16:57:00ZNeutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment10.1038/s41467-018-05178-52041-1723https://doaj.org/article/910fcb79df52422ca7960ee3a2ab082f2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05178-5https://doaj.org/toc/2041-1723Enhancement of haematopoietic stem cell (HSC) homing and engraftment is critical for haematopoietic cell transplantation. Here, the authors find that HDAC5 inhibition enhances HSC homing and engraftment by increasing p65 acetylation and enhancing NF-kB mediated CXCR4 transcription.Xinxin HuangBin GuoSheng LiuJun WanHal E. BroxmeyerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinxin Huang Bin Guo Sheng Liu Jun Wan Hal E. Broxmeyer Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
description	Enhancement of haematopoietic stem cell (HSC) homing and engraftment is critical for haematopoietic cell transplantation. Here, the authors find that HDAC5 inhibition enhances HSC homing and engraftment by increasing p65 acetylation and enhancing NF-kB mediated CXCR4 transcription.
format	article
author	Xinxin Huang Bin Guo Sheng Liu Jun Wan Hal E. Broxmeyer
author_facet	Xinxin Huang Bin Guo Sheng Liu Jun Wan Hal E. Broxmeyer
author_sort	Xinxin Huang
title	Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
title_short	Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
title_full	Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
title_fullStr	Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
title_full_unstemmed	Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
title_sort	neutralizing negative epigenetic regulation by hdac5 enhances human haematopoietic stem cell homing and engraftment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/910fcb79df52422ca7960ee3a2ab082f
work_keys_str_mv	AT xinxinhuang neutralizingnegativeepigeneticregulationbyhdac5enhanceshumanhaematopoieticstemcellhomingandengraftment AT binguo neutralizingnegativeepigeneticregulationbyhdac5enhanceshumanhaematopoieticstemcellhomingandengraftment AT shengliu neutralizingnegativeepigeneticregulationbyhdac5enhanceshumanhaematopoieticstemcellhomingandengraftment AT junwan neutralizingnegativeepigeneticregulationbyhdac5enhanceshumanhaematopoieticstemcellhomingandengraftment AT halebroxmeyer neutralizingnegativeepigeneticregulationbyhdac5enhanceshumanhaematopoieticstemcellhomingandengraftment
_version_	1718382636456476672

Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

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