Inflammatory breast cancer: a model for investigating cluster-based dissemination

Abstract Metastases claim more than 90% of cancer-related patient deaths and are usually seeded by a subset of circulating tumor cells shed off from the primary tumor. In circulation, circulating tumor cells are found both as single cells and as clusters of cells. The clusters of circulating tumor c...

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Autores principales:	Mohit Kumar Jolly, Marcelo Boareto, Bisrat G. Debeb, Nicola Aceto, Mary C. Farach-Carson, Wendy A. Woodward, Herbert Levine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/911366c914c54315a28d13d968652f8a
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spelling	oai:doaj.org-article:911366c914c54315a28d13d968652f8a2021-12-02T16:19:49ZInflammatory breast cancer: a model for investigating cluster-based dissemination10.1038/s41523-017-0023-92374-4677https://doaj.org/article/911366c914c54315a28d13d968652f8a2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0023-9https://doaj.org/toc/2374-4677Abstract Metastases claim more than 90% of cancer-related patient deaths and are usually seeded by a subset of circulating tumor cells shed off from the primary tumor. In circulation, circulating tumor cells are found both as single cells and as clusters of cells. The clusters of circulating tumor cells, although many fewer in number, possess much higher metastatic potential as compared to that of individual circulating tumor cells. In this review, we highlight recent insights into molecular mechanisms that can enable the formation of these clusters—(a) hybrid epithelial/mesenchymal phenotype of cells that couples their ability to migrate and adhere, and (b) intercellular communication that can spatially coordinate the cluster formation and provide survival signals to cancer cells. Building upon these molecular mechanisms, we also offer a possible mechanistic understanding of why clusters are endowed with a higher metastatic potential. Finally, we discuss the highly aggressive Inflammatory Breast Cancer as an example of a carcinoma that can metastasize via clusters and corroborates the proposed molecular mechanisms.Mohit Kumar JollyMarcelo BoaretoBisrat G. DebebNicola AcetoMary C. Farach-CarsonWendy A. WoodwardHerbert LevineNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mohit Kumar Jolly Marcelo Boareto Bisrat G. Debeb Nicola Aceto Mary C. Farach-Carson Wendy A. Woodward Herbert Levine Inflammatory breast cancer: a model for investigating cluster-based dissemination
description	Abstract Metastases claim more than 90% of cancer-related patient deaths and are usually seeded by a subset of circulating tumor cells shed off from the primary tumor. In circulation, circulating tumor cells are found both as single cells and as clusters of cells. The clusters of circulating tumor cells, although many fewer in number, possess much higher metastatic potential as compared to that of individual circulating tumor cells. In this review, we highlight recent insights into molecular mechanisms that can enable the formation of these clusters—(a) hybrid epithelial/mesenchymal phenotype of cells that couples their ability to migrate and adhere, and (b) intercellular communication that can spatially coordinate the cluster formation and provide survival signals to cancer cells. Building upon these molecular mechanisms, we also offer a possible mechanistic understanding of why clusters are endowed with a higher metastatic potential. Finally, we discuss the highly aggressive Inflammatory Breast Cancer as an example of a carcinoma that can metastasize via clusters and corroborates the proposed molecular mechanisms.
format	article
author	Mohit Kumar Jolly Marcelo Boareto Bisrat G. Debeb Nicola Aceto Mary C. Farach-Carson Wendy A. Woodward Herbert Levine
author_facet	Mohit Kumar Jolly Marcelo Boareto Bisrat G. Debeb Nicola Aceto Mary C. Farach-Carson Wendy A. Woodward Herbert Levine
author_sort	Mohit Kumar Jolly
title	Inflammatory breast cancer: a model for investigating cluster-based dissemination
title_short	Inflammatory breast cancer: a model for investigating cluster-based dissemination
title_full	Inflammatory breast cancer: a model for investigating cluster-based dissemination
title_fullStr	Inflammatory breast cancer: a model for investigating cluster-based dissemination
title_full_unstemmed	Inflammatory breast cancer: a model for investigating cluster-based dissemination
title_sort	inflammatory breast cancer: a model for investigating cluster-based dissemination
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/911366c914c54315a28d13d968652f8a
work_keys_str_mv	AT mohitkumarjolly inflammatorybreastcanceramodelforinvestigatingclusterbaseddissemination AT marceloboareto inflammatorybreastcanceramodelforinvestigatingclusterbaseddissemination AT bisratgdebeb inflammatorybreastcanceramodelforinvestigatingclusterbaseddissemination AT nicolaaceto inflammatorybreastcanceramodelforinvestigatingclusterbaseddissemination AT marycfarachcarson inflammatorybreastcanceramodelforinvestigatingclusterbaseddissemination AT wendyawoodward inflammatorybreastcanceramodelforinvestigatingclusterbaseddissemination AT herbertlevine inflammatorybreastcanceramodelforinvestigatingclusterbaseddissemination
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Inflammatory breast cancer: a model for investigating cluster-based dissemination

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