Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model

Abstract Mucus clearance, a primary innate defense mechanism of airways, is defective in patients with cystic fibrosis (CF) and CF animals. In previous work, the combination of a low dose of the cholinergic agonist, carbachol with forskolin or a β adrenergic agonist, isoproterenol synergistically in...

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Autores principales: Nam Soo Joo, Hyung-Ju Cho, Meagan Shinbashi, Jae Young Choi, Carlos E. Milla, John F. Engelhardt, Jeffrey J. Wine
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/91154804265f4012ae9f1330a2cf12f1
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