IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

The pathogenic mechanisms of cardiorenal syndrome type 4 (CRS4) remain unclear. Here, the authors identify IRF1-PGC1α axis-mediated myocardial energy metabolism remodeling as a contributor to CRS4 pathogenesis, thus providing potential new targets for reducing cardiovascular events in CKD patients.

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Auteurs principaux: Yinghui Huang, Shaobo Wang, Jie Zhou, Yong Liu, Changhong Du, Ke Yang, Xianjin Bi, Mingying Liu, Wenhao Han, Kailong Wang, Jiachuan Xiong, Song Wang, Yue Wang, Ling Nie, Chi Liu, Daohai Zhang, Jun Gu, Chunyu Zeng, Jinghong Zhao
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/9118889ff39a40bc8862c547ee73f4a2
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Résumé:The pathogenic mechanisms of cardiorenal syndrome type 4 (CRS4) remain unclear. Here, the authors identify IRF1-PGC1α axis-mediated myocardial energy metabolism remodeling as a contributor to CRS4 pathogenesis, thus providing potential new targets for reducing cardiovascular events in CKD patients.

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