IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

The pathogenic mechanisms of cardiorenal syndrome type 4 (CRS4) remain unclear. Here, the authors identify IRF1-PGC1α axis-mediated myocardial energy metabolism remodeling as a contributor to CRS4 pathogenesis, thus providing potential new targets for reducing cardiovascular events in CKD patients.

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Autores principales:	Yinghui Huang, Shaobo Wang, Jie Zhou, Yong Liu, Changhong Du, Ke Yang, Xianjin Bi, Mingying Liu, Wenhao Han, Kailong Wang, Jiachuan Xiong, Song Wang, Yue Wang, Ling Nie, Chi Liu, Daohai Zhang, Jun Gu, Chunyu Zeng, Jinghong Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9118889ff39a40bc8862c547ee73f4a2
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spelling	oai:doaj.org-article:9118889ff39a40bc8862c547ee73f4a22021-12-02T17:23:48ZIRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 410.1038/s41467-020-18519-02041-1723https://doaj.org/article/9118889ff39a40bc8862c547ee73f4a22020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18519-0https://doaj.org/toc/2041-1723The pathogenic mechanisms of cardiorenal syndrome type 4 (CRS4) remain unclear. Here, the authors identify IRF1-PGC1α axis-mediated myocardial energy metabolism remodeling as a contributor to CRS4 pathogenesis, thus providing potential new targets for reducing cardiovascular events in CKD patients.Yinghui HuangShaobo WangJie ZhouYong LiuChanghong DuKe YangXianjin BiMingying LiuWenhao HanKailong WangJiachuan XiongSong WangYue WangLing NieChi LiuDaohai ZhangJun GuChunyu ZengJinghong ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yinghui Huang Shaobo Wang Jie Zhou Yong Liu Changhong Du Ke Yang Xianjin Bi Mingying Liu Wenhao Han Kailong Wang Jiachuan Xiong Song Wang Yue Wang Ling Nie Chi Liu Daohai Zhang Jun Gu Chunyu Zeng Jinghong Zhao IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4
description	The pathogenic mechanisms of cardiorenal syndrome type 4 (CRS4) remain unclear. Here, the authors identify IRF1-PGC1α axis-mediated myocardial energy metabolism remodeling as a contributor to CRS4 pathogenesis, thus providing potential new targets for reducing cardiovascular events in CKD patients.
format	article
author	Yinghui Huang Shaobo Wang Jie Zhou Yong Liu Changhong Du Ke Yang Xianjin Bi Mingying Liu Wenhao Han Kailong Wang Jiachuan Xiong Song Wang Yue Wang Ling Nie Chi Liu Daohai Zhang Jun Gu Chunyu Zeng Jinghong Zhao
author_facet	Yinghui Huang Shaobo Wang Jie Zhou Yong Liu Changhong Du Ke Yang Xianjin Bi Mingying Liu Wenhao Han Kailong Wang Jiachuan Xiong Song Wang Yue Wang Ling Nie Chi Liu Daohai Zhang Jun Gu Chunyu Zeng Jinghong Zhao
author_sort	Yinghui Huang
title	IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4
title_short	IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4
title_full	IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4
title_fullStr	IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4
title_full_unstemmed	IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4
title_sort	irf1-mediated downregulation of pgc1α contributes to cardiorenal syndrome type 4
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9118889ff39a40bc8862c547ee73f4a2
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IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

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