M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE

Microfold cells (M cells) are specialized intestinal epithelial cells that initiate mucosal immune responses. These unique phagocytic epithelial cells are specialized for the transfer of a broad range of particulate antigens and microorganisms across the follicle-associated epithelium (FAE) into the...

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Autores principales:	A. S. Bykov, A. V. Karaulov, D. A. Tsomartova, N. L. Kartashkina, V. L. Goriachkina, S. L. Kuznetsov, D. A. Stonogina, Ye. V. Chereshneva
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Materias:	antigen galt m cells rankl transcytosis mucosal immunity vaccines Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/911aa53b073840f8b6118d23bb783c89
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spelling	oai:doaj.org-article:911aa53b073840f8b6118d23bb783c892021-11-22T07:09:49ZM CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE2220-76192313-739810.15789/2220-7619-2018-3-263-272https://doaj.org/article/911aa53b073840f8b6118d23bb783c892018-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/776https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Microfold cells (M cells) are specialized intestinal epithelial cells that initiate mucosal immune responses. These unique phagocytic epithelial cells are specialized for the transfer of a broad range of particulate antigens and microorganisms across the follicle-associated epithelium (FAE) into the gut-associated lymphoid tissue (GALT) by a process termed transcytosis. The molecular basis of antigen uptake by M cells has been gradually identified in the last decade. Active sampling of intestinal antigen initiates regulated immune responses that ensure intestinal homeostasis. The delivery of luminal substances across the intestinal epithelium to the immune system is a critical event in immune surveillance resulting in tolerance to dietary antigens and immunity to pathogens (e.g., bacteria, viruses, and parasites) and their toxins. Several specialized mechanisms transport luminal antigen across the gut epithelium. Discovery of M cell-specific receptors are of great interest, which could act as molecular tags for targeted delivery oral vaccine to M cells. Recent studies demonstrated that M cells utilize several receptors to recognize and transport specific luminal antigens. Vaccination through the mucosal immune system can induce effective systemic immune responses simultaneously with mucosal immunity. How this process is regulated is largely unknown. This review aims to show a new understanding of the factors that influence the development and function of M cells; to show the molecules expressed on M cells which appear to be used as immunosurveillance receptors to sample pathogenic microorganisms in the gut; to note how certain pathogens appear to exploit M cells to inject the host; and, finally, how this knowledge is used to specifically "target" antigens to M cells to attempt to improve the efficacy of mucosal vaccines. Recently, substantial progress has been made in our understanding of the factors that influence the development and function of M cells.A. S. BykovA. V. KaraulovD. A. TsomartovaN. L. KartashkinaV. L. GoriachkinaS. L. KuznetsovD. A. StonoginaYe. V. ChereshnevaSankt-Peterburg : NIIÈM imeni Pasteraarticleantigengaltm cellsrankltranscytosismucosal immunityvaccinesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 8, Iss 3, Pp 263-272 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	antigen galt m cells rankl transcytosis mucosal immunity vaccines Infectious and parasitic diseases RC109-216
spellingShingle	antigen galt m cells rankl transcytosis mucosal immunity vaccines Infectious and parasitic diseases RC109-216 A. S. Bykov A. V. Karaulov D. A. Tsomartova N. L. Kartashkina V. L. Goriachkina S. L. Kuznetsov D. A. Stonogina Ye. V. Chereshneva M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE
description	Microfold cells (M cells) are specialized intestinal epithelial cells that initiate mucosal immune responses. These unique phagocytic epithelial cells are specialized for the transfer of a broad range of particulate antigens and microorganisms across the follicle-associated epithelium (FAE) into the gut-associated lymphoid tissue (GALT) by a process termed transcytosis. The molecular basis of antigen uptake by M cells has been gradually identified in the last decade. Active sampling of intestinal antigen initiates regulated immune responses that ensure intestinal homeostasis. The delivery of luminal substances across the intestinal epithelium to the immune system is a critical event in immune surveillance resulting in tolerance to dietary antigens and immunity to pathogens (e.g., bacteria, viruses, and parasites) and their toxins. Several specialized mechanisms transport luminal antigen across the gut epithelium. Discovery of M cell-specific receptors are of great interest, which could act as molecular tags for targeted delivery oral vaccine to M cells. Recent studies demonstrated that M cells utilize several receptors to recognize and transport specific luminal antigens. Vaccination through the mucosal immune system can induce effective systemic immune responses simultaneously with mucosal immunity. How this process is regulated is largely unknown. This review aims to show a new understanding of the factors that influence the development and function of M cells; to show the molecules expressed on M cells which appear to be used as immunosurveillance receptors to sample pathogenic microorganisms in the gut; to note how certain pathogens appear to exploit M cells to inject the host; and, finally, how this knowledge is used to specifically "target" antigens to M cells to attempt to improve the efficacy of mucosal vaccines. Recently, substantial progress has been made in our understanding of the factors that influence the development and function of M cells.
format	article
author	A. S. Bykov A. V. Karaulov D. A. Tsomartova N. L. Kartashkina V. L. Goriachkina S. L. Kuznetsov D. A. Stonogina Ye. V. Chereshneva
author_facet	A. S. Bykov A. V. Karaulov D. A. Tsomartova N. L. Kartashkina V. L. Goriachkina S. L. Kuznetsov D. A. Stonogina Ye. V. Chereshneva
author_sort	A. S. Bykov
title	M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE
title_short	M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE
title_full	M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE
title_fullStr	M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE
title_full_unstemmed	M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE
title_sort	m cells are the important post in the initiation of immune response in intestine
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/911aa53b073840f8b6118d23bb783c89
work_keys_str_mv	AT asbykov mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine AT avkaraulov mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine AT datsomartova mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine AT nlkartashkina mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine AT vlgoriachkina mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine AT slkuznetsov mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine AT dastonogina mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine AT yevchereshneva mcellsaretheimportantpostintheinitiationofimmuneresponseinintestine
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M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE

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