Analysis of Phytonutrients, Anti-Mutagenic and Chemopreventive Effects of Tropical Fruit Extracts
Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes,...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/911c18de03f84a77a839004ca0965664 |
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| Sumario: | Thailand is located in the tropics and a wide variety of fruits are grown commercially. However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects of these fruits are limited. Thus, phytochemical profiles and inhibition of key enzymes involved in obesity and diabetes, together with anti-mutagenic and chemopreventive properties of eight tropical fruit extracts cultivated in Thailand, including <i>Psidium guajava</i> ‘Kimju’, <i>Psidium guajava</i> ‘Keenok’, <i>Ananas comosus</i> ‘Pattavia’, <i>Ananas comosus</i> ‘Phulae’, <i>Durio zibethinus</i> ‘Chanee’, <i>Durio zibethinus</i> ‘Monthong’, <i>Carica papaya</i> ‘Khaekdum’ and <i>Mangifera indica</i> ‘Namdokmai’ were investigated. Different cultivars were also compared. Results showed that <i>M. indica</i> ‘Namdokmai’ was the most antioxidant-rich extract containing abundant 4-hydroxybenzoic acid and its derivative, gallic acid, as the main phenolics. <i>M. indica</i> ‘Namdokmai’ also exhibited high inhibitory capacities (>60% inhibition under studied conditions) against lipase, α-amylase and α-glucosidase, key enzymes as drug targets for controlling obesity and type 2 diabetes. Interestingly, all fruit extracts suppressed food mutagen-induced DNA mutations assayed by the Ames test, especially <i>M. indica</i> ‘Namdokmai’ and <i>C. papaya</i> ‘Khaekdum’ (>50% inhibition at 200 µg/plate). The <i>M. indica</i> ‘Namdokmai’ was also the most potent extract for suppression of cancer promotion (>90% inhibition at 200 µg/mL) followed by <i>P. guajava</i> ‘Kimju’, <i>P. guajava</i> ‘Keenok’ and <i>C. papaya</i> ‘Khaekdum’. Results potentially indicated that fruit intake after overcooked meat consumption might supplement nutrients and fiber and also reduce DNA mutation sources. |
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